Diamond J G
Arch Ophthalmol. 1976 Jan;94(1):41-7. doi: 10.1001/archopht.1976.03910030007004.
In patients with open-angle glaucoma, subconjunctival injection of 6-hydroxydopamine produced chemical sympathectomy and sensitization to topically applied epinephrine. Prior to entry into this study, all patients had intraocular pressures (IOPs) greater than 30 mm Hg and had not responded to maximal medical therapy. The 6-hydroxydopamine was prepared in an ascorbic acid-buffered solution and was well tolerated by the patients. After subconjunctival administration of 6-hydroxydopamine, the mean decrease in IOPs was 50% in the treated eyes and 5% in the contraleteral eyes. Topical administration of 1% epinephrine to eyes injected with 6-hydroxydopamine resulted in a mean fall of IOP of 40% that persisted for as long as three months. Repeated subconjunctival injections of 6-hydroxydopamine renewed the pressure-lowering effects and sensitization to topically applied epinephrine.
在开角型青光眼患者中，结膜下注射6-羟基多巴胺可产生化学性交感神经切除术，并使眼部对局部应用的肾上腺素敏感。在进入本研究之前，所有患者的眼压（IOP）均高于30 mmHg，且对最大程度的药物治疗无反应。6-羟基多巴胺用抗坏血酸缓冲溶液配制，患者耐受性良好。结膜下注射6-羟基多巴胺后，治疗眼的眼压平均降低50%，对侧眼降低5%。对注射了6-羟基多巴胺的眼睛局部应用1%肾上腺素，可使眼压平均下降40%，且这种效果可持续长达三个月。重复结膜下注射6-羟基多巴胺可恢复降压效果，并使眼部对局部应用的肾上腺素重新敏感。
