Mawson Anthony R, WaKabongo Musau
Institute of Epidemiology and Health Services Research, Jackson State University, 350 Woodrow Wilson Avenue, Suite 2301-B, Jackson, MS 39213, USA.
Trans R Soc Trop Med Hyg. 2002 Sep-Oct;96(5):541-2. doi: 10.1016/s0035-9203(02)90434-7.
Tissue concentrations of vitamin A in Onchocerca volvulus are about 8 times higher than those of the host. About 100,000 microfilariae (mf) die every day in heavily infected persons. Onchocerciasis-associated morbidity may be due in part to the release of retinoids from dying mf and their gradual accumulation to toxic concentrations in affected tissues.
盘尾丝虫体内维生素A的组织浓度比宿主高约8倍。在重度感染人群中，每天约有100,000条微丝蚴死亡。盘尾丝虫病相关的发病率可能部分归因于垂死微丝蚴释放类视黄醇以及它们在受影响组织中逐渐积累至有毒浓度。
