Lewy-Trenda Iwona
Pracownia Neuropatologii Katedra i Zakład Patomorfologii Akademii Medycznej w Łodzi.
Pol Merkur Lekarski. 2002 Sep;13(75):225-8.
Angiogenesis is a process of new blood vessels formation in many physiological and pathological conditions such as wound healing, cancer, ischaemic diseases (of heart or limb) and chronic inflammations. Neoplastic angiogenesis plays an important role in progression of the disease and development of metastases. The angiogenic process may be initiated by hypoxia in cancerous cells, mutations in suppressor genes or oncogenes. Cancer cells activate specific angiogenic factors mainly vasoendothelial growth factor (VEGF) that stimulate migration and division of vascular endothelial cells. The studies of several pro- and antiangiogenic molecules and factors, and mechanism of vessel growth, have revealed that therapeutic interferences with these processes offers a tool for clinical applications in various pathologies. Inhibition of angiogenesis can prevent diseases with excessive vessel growth such as, particularly, cancers. Stimulation of angiogenesis can be beneficial in the treatment of diseases such as coronary disease and limb ischaemia. In this article some aspects are presented of current knowledge of angiogenesis and its regulation.
血管生成是在许多生理和病理状况下新血管形成的过程，如伤口愈合、癌症、（心脏或肢体的）缺血性疾病以及慢性炎症。肿瘤血管生成在疾病进展和转移发展中起重要作用。血管生成过程可能由癌细胞中的缺氧、抑癌基因或癌基因突变引发。癌细胞激活特定的血管生成因子，主要是血管内皮生长因子（VEGF），其刺激血管内皮细胞迁移和分裂。对几种促血管生成和抗血管生成分子及因子以及血管生长机制的研究表明，对这些过程进行治疗干预为各种病理学的临床应用提供了一种工具。抑制血管生成可预防血管过度生长的疾病，尤其是癌症。刺激血管生成在治疗冠状动脉疾病和肢体缺血等疾病中可能有益。本文介绍了血管生成及其调节的当前知识的一些方面。
