Kuo Winston Patrick, Jenssen Tor-Kristian, Park Peter J, Lingen Mark W, Hasina Rifat, Ohno-Machado Lucila
Decision Systems Group, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Proc AMIA Symp. 2002:415-9.
Oral squamous cell carcinoma (OSCC) is one of the most common cancer types worldwide. The prognosis for patients with this disease is generally poor and little is known about its progression. Gene expression studies may provide important insights to the molecular mechanisms of this disease. We analyzed gene expression data from a small panel of patients diagnosed with OSCC. Even with only 13 patient samples we were able to find genes with significant differences in expression levels between normal, dysplasia, and cancer samples. The largest differences in expression were generally found between normal and cancer samples, but significant differences were also found for several genes between dysplasia and the other two sample types. We also represent the significance levels of differentially expressed genes on the chromosome domain. The genes and genetic features we examine are potentially important factors on the molecular level in the progression of OSCC.
口腔鳞状细胞癌（OSCC）是全球最常见的癌症类型之一。这种疾病患者的预后通常较差，对其进展了解甚少。基因表达研究可能为该疾病的分子机制提供重要见解。我们分析了一小组被诊断为OSCC患者的基因表达数据。即使只有13个患者样本，我们也能够找到在正常、发育异常和癌症样本之间表达水平存在显著差异的基因。表达差异最大的通常是在正常样本和癌症样本之间，但在发育异常样本与其他两种样本类型之间的几个基因也发现了显著差异。我们还展示了差异表达基因在染色体区域上的显著性水平。我们所研究的基因和遗传特征可能是OSCC进展在分子水平上的潜在重要因素。
