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Precursor processing by kex2/furin proteases.

作者信息

Rockwell Nathan C, Krysan Damian J, Komiyama Tomoko, Fuller Robert S

机构信息

Department of Biological Chemistry, University of Michigan Medical Center, Room 5413 Med Sci I, 1301 East Catherine, Ann Arbor Michigan 48109, USA.

出版信息

Chem Rev. 2002 Dec;102(12):4525-48. doi: 10.1021/cr010168i.

DOI:10.1021/cr010168i
PMID:12475200
Abstract
摘要

相似文献

1
Precursor processing by kex2/furin proteases.由kex2/弗林蛋白酶进行前体加工。
Chem Rev. 2002 Dec;102(12):4525-48. doi: 10.1021/cr010168i.
2
The kindest cuts of all: crystal structures of Kex2 and furin reveal secrets of precursor processing.最温和的切割:Kex2和弗林蛋白酶的晶体结构揭示前体加工的秘密。
Trends Biochem Sci. 2004 Feb;29(2):80-7. doi: 10.1016/j.tibs.2003.12.006.
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Structure and function of eukaryotic proprotein processing enzymes of the subtilisin family of serine proteases.丝氨酸蛋白酶枯草杆菌蛋白酶家族真核前蛋白加工酶的结构与功能
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4
Direct measurement of acylenzyme hydrolysis demonstrates rate-limiting deacylation in cleavage of physiological sequences by the processing protease Kex2.对酰基酶水解的直接测量表明,在加工蛋白酶Kex2切割生理序列的过程中,脱酰基是限速步骤。
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5
Differential utilization of enzyme-substrate interactions for acylation but not deacylation during the catalytic cycle of Kex2 protease.在Kex2蛋白酶催化循环中,酶 - 底物相互作用在酰化而非去酰化过程中的差异利用。
J Biol Chem. 2001 Oct 19;276(42):38394-9. doi: 10.1074/jbc.M105782200. Epub 2001 Aug 20.
6
Interplay between S1 and S4 subsites in Kex2 protease: Kex2 exhibits dual specificity for the P4 side chain.Kex2蛋白酶中S1和S4亚位点之间的相互作用:Kex2对P4侧链表现出双重特异性。
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7
Engineered eglin c variants inhibit yeast and human proprotein processing proteases, Kex2 and furin.工程化的依吉林c变体可抑制酵母和人类前蛋白加工蛋白酶Kex2和弗林蛋白酶。
Biochemistry. 2000 Dec 12;39(49):15156-65. doi: 10.1021/bi001907c.
8
Quantitative characterization of furin specificity. Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methylcoumarinamides.弗林蛋白酶特异性的定量表征。使用一组内部一致的六肽基甲基香豆素酰胺进行底物识别的能量学研究。
J Biol Chem. 1999 Aug 13;274(33):23229-34. doi: 10.1074/jbc.274.33.23229.
9
Yeast and mammalian basic residue-specific aspartic proteases in prohormone conversion.酵母和哺乳动物中参与激素原转化的碱性残基特异性天冬氨酸蛋白酶
Adv Exp Med Biol. 1995;362:519-27. doi: 10.1007/978-1-4615-1871-6_68.
10
[A family of Kex2-like endoproteases involved in processing of precursors for biologically active peptides and proteins].[参与生物活性肽和蛋白质前体加工的一类Kex2样内切蛋白酶]
Seikagaku. 1995 Aug;67(8):995-1009.

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