毛细血管扩张性骨肉瘤：14例临床病理分析

Telangiectatic osteosarcoma: a clinicopathologic analysis of 14 cases.

作者信息

Liu Honghong, Huang Xiaoyuan

机构信息

Department of Pathology, Beijing Jishuitan Hospital, Beijing 100035, China.

出版信息

Zhonghua Bing Li Xue Za Zhi. 2002 Jun;31(3):213-6.

PMID:12475437

Abstract

OBJECTIVE

To investigate the clinicopathologic characteritics and prognosis of telangiectatic osteosarcoma.

METHODS

The clinical and pathological data of 14 cases of telangiectatic osteosarcoma were reviewed.

RESULTS

Most of these patients were male (9/14). The mean age was 23 years. Most tumors were located in the lower extremities (10/14). The roentgenograms showed a large purely osteolytic lesion. Both medullar and cortical bone were extensively destroyed. The gross specimen showed cystic cavities separated by septa, similar to an aneurismal bone cyst. Microscopically, the septa contained anaplastic cells. A few fine, lace-like osteoid were scattered among these sarcomatous cells. 12 patients were followed-up from 6 months to 84 months. Of seven patients who had developed pulmonary metastasis, six patients died and one alive with lung metastasis. The remaining five patients survived after operation.

CONCLUSIONS

Difficulties in making an early diagnosis and highly malignant of this disease might be the important factors that affect the prognosis of telangiectatic osteosarcoma.

摘要

目的

探讨毛细血管扩张型骨肉瘤的临床病理特征及预后。

方法

回顾性分析14例毛细血管扩张型骨肉瘤的临床及病理资料。

结果

这些患者多数为男性（9/14）。平均年龄为23岁。多数肿瘤位于下肢（10/14）。X线片显示为大片单纯溶骨性病变。骨髓和皮质骨均被广泛破坏。大体标本显示有被间隔分隔的囊腔，类似骨囊肿。镜下，间隔内可见间变细胞。在这些肉瘤细胞中散在少量纤细的、花边样的骨样组织。12例患者进行了6个月至84个月的随访。7例发生肺转移的患者中，6例死亡，1例带肺转移存活。其余5例患者术后存活。