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获取水稻基因组序列及在此过程中获得的经验教训。

Obtaining the sequence of the rice genome and lessons learned along the way.

作者信息

Buell C Robin

机构信息

The Institute for Genomic Research, Rockville, MD 20850, USA.

出版信息

Trends Plant Sci. 2002 Dec;7(12):538-42. doi: 10.1016/s1360-1385(02)02369-5.

DOI:10.1016/s1360-1385(02)02369-5
PMID:12475494
Abstract

Rice holds the record for the largest number of separate genome projects and for having the genome of two subspecies sequenced. This might be a short-lived record in the genomics era, but it highlights the significance of rice as a food staple and as a model plant for cereal species. Clearly, obtaining the genome sequence four times seems redundant, yet the rationale and motivation for each of these projects is valid; whether it is serving corporate shareholders or the general scientific community. Although the multiple projects resulted in some duplicated efforts, the value of data sharing was obvious and the winner in the end will be the global public.

摘要

水稻在独立基因组项目数量最多以及两个亚种基因组测序方面保持着纪录。在基因组学时代,这一纪录可能只是昙花一现,但它凸显了水稻作为主食和谷类作物模式植物的重要性。显然,对基因组序列进行四次测序看似多余,但每个项目的基本原理和动机都是合理的;无论是为了服务企业股东还是广大科学界。尽管多个项目导致了一些重复劳动,但数据共享的价值是显而易见的,最终的赢家将是全球公众。

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引用本文的文献

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The Genomes of Oryza sativa: a history of duplications.水稻基因组:重复序列的历史
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2
Structural and functional analysis of rice genome.水稻基因组的结构与功能分析
J Genet. 2004 Apr;83(1):79-99. doi: 10.1007/BF02715832.
3
Conserved noncoding sequences among cultivated cereal genomes identify candidate regulatory sequence elements and patterns of promoter evolution.栽培谷物基因组中的保守非编码序列可识别候选调控序列元件及启动子进化模式。
Plant Cell. 2003 May;15(5):1143-58. doi: 10.1105/tpc.010181.