口腔肿瘤进展中嗜银核仁组成区的评估

Evaluation of argyrophilic nucleolar organizer regions in oral tumor progression.

作者信息

Spolidorio L C, Neves K A, Soares C P, Spolidorio D M P, Basso M F M, Malavazzi I, Almeida O P

机构信息

Department of Oral Pathology, Araraquara Dental School, University of São Paulo State, Rua Humaitá, 1680 CEP, 14801-903 Araraquara, Brazil.

出版信息

Micron. 2002;33(7-8):605-8. doi: 10.1016/s0968-4328(02)00031-8.

DOI:10.1016/s0968-4328(02)00031-8

PMID:12475557

Abstract

The aim of this study was to compare the presence of nucleolar organizer regions (NORs) in normal oral mucosa, dysplasia and microinvasive carcinoma. All histological specimens were reviewed according to the modified classification and staging system for oral leukoplakia described by van-der-Waal et al. [Oral Oncol. 36 (2000) 264]. NOR quantification was performed with an image analyzer after staining by the argyrophilic nucleolar region technique. The morphometric results were statistically different for normal mucosa, dysplasia and microinvasive carcinoma. It was concluded that an increase of NOR activity follows the disease progression and may reflect the degree of cellular proliferation and malignancy.

摘要

本研究旨在比较正常口腔黏膜、发育异常及微侵袭癌中核仁组织区（NORs）的存在情况。所有组织学标本均根据van-der-Waal等人描述的口腔白斑改良分类和分期系统进行复查[《口腔肿瘤学》36卷（2000年）264页]。采用嗜银核仁区技术染色后，用图像分析仪进行NOR定量分析。正常黏膜、发育异常及微侵袭癌的形态计量学结果存在统计学差异。研究得出结论，NOR活性的增加随疾病进展而出现，可能反映细胞增殖和恶性程度。