Pillai K R, Sujathan K, Kannan S, Abraham E K, Mathew B, Amma N S, Nair M K, Menon V P
Division of Cytopathology, Regional Cancer Centre, Thiruvananthapuram, India.
J Cancer Res Clin Oncol. 1994;120(12):723-6. doi: 10.1007/BF01194270.
The present study has analysed the numbers of argyrophilic nucleolar organizer regions (AgNOR) in normal tissues and in premalignant and malignant lesions of the oral mucosa in order to assess their potential as a biological marker for tumour progression. On comparison of AgNOR numbers in different lesions, carcinomas showed the highest number (4.65 +/- 0.98) compared to leukoplakias (2.38 +/- 0.47) and normal tissues (1.53 +/- 0.39). Spindle cell carcinomas and poorly differentiated squamous cell carcinomas had higher AgNOR counts than well-differentiated carcinomas. In various clinically different types of oral leukoplakia, the lowest AgNOR counts were observed in homogenous leukoplakia and the highest in speckled leukoplakia. No significant difference in AgNOR number was observed between non-dysplastic and dysplastic leukoplakia, although a significant difference was evident between dysplastic leukoplakia and normal oral mucosa. Correlating the AgNOR count and tumour progression, a significantly high positive correlation coefficient (r = 0.7969, P = 0.0000) was observed.
本研究分析了正常组织以及口腔黏膜癌前病变和恶性病变中嗜银核仁组织区（AgNOR）的数量，以评估其作为肿瘤进展生物学标志物的潜力。比较不同病变中的AgNOR数量，与白斑（2.38±0.47）和正常组织（1.53±0.39）相比，癌显示出最高数量（4.65±0.98）。梭形细胞癌和低分化鳞状细胞癌的AgNOR计数高于高分化癌。在临床上不同类型的口腔白斑中，均质型白斑的AgNOR计数最低，斑点状白斑的AgNOR计数最高。非发育异常和发育异常的白斑之间未观察到AgNOR数量的显著差异，尽管发育异常的白斑与正常口腔黏膜之间存在明显差异。将AgNOR计数与肿瘤进展相关联，观察到显著高的正相关系数（r = 0.7969，P = 0.0000）。
