Usdin Ted B, Dobolyi Arpad, Ueda Hiroshi, Palkovits Miklós
Laboratory of Genetics, National Institute of Mental Health, National Institutes of Health, Building 36/Room 3D06, 36 Convent Drive, Bethesda, MD 20892-4094, USA.
Trends Endocrinol Metab. 2003 Jan;14(1):14-9. doi: 10.1016/s1043-2760(02)00002-4.
Tuberoinfundibular peptide of 39 residues (TIP39), a neuropeptide recently purified from the hypothalamus, appears to be an endogenous ligand for the parathyroid hormone 2 (PTH2) receptor. PTH2 receptors are present in several central nervous system and peripheral areas and are particularly concentrated in the hypothalamus, limbic areas and the outer layers of the spinal cord dorsal horn. TIP39-containing neuronal cell bodies have been identified in the subparafascicular area and the medial paralemniscal nucleus, two brainstem regions that project widely through the entire neuraxis. Treatment of hypothalamic explants with TIP39, and intraventricular injection of the peptide, suggest that it might stimulate hypothalamic-releasing factor secretion. Injection of TIP39, and sequestration of endogenous TIP39 by intrathecal injection of an antibody to TIP39, have provided evidence that it is involved in some aspects of pain sensitivity. Thus, TIP39 might be a new neuromodulator.
39个氨基酸残基的结节漏斗肽（TIP39）是一种最近从下丘脑纯化出来的神经肽，它似乎是甲状旁腺激素2（PTH2）受体的内源性配体。PTH2受体存在于几个中枢神经系统和外周区域，尤其集中在下丘脑、边缘系统区域以及脊髓背角外层。在束旁下区和内侧旁臂核中已鉴定出含有TIP39的神经元细胞体，这两个脑干区域广泛投射至整个神经轴。用TIP39处理下丘脑外植体以及脑室内注射该肽，提示它可能刺激下丘脑释放因子的分泌。注射TIP39以及通过鞘内注射TIP39抗体来隔离内源性TIP39，均已证明它参与疼痛敏感性的某些方面。因此，TIP39可能是一种新的神经调节剂。
