伟大的思想自由驰骋。新型朊病毒生物学会议：基础科学、诊断与治疗
Grand ideas floating freely. Conference on the new prion biology: basic science, diagnosis and therapy.
作者信息
Chesebro Bruce
机构信息
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institute of Health, Hamilton, MT 59840, USA.
出版信息
EMBO Rep. 2002 Dec;3(12):1123-6. doi: 10.1093/embo-reports/kvf256.
Abstract
Conference on the new prion biology: basic science, diagnosis and therapy
摘要
新型朊病毒生物学会议
基础科学、诊断与治疗
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Grand ideas floating freely. Conference on the new prion biology: basic science, diagnosis and therapy.伟大的思想自由驰骋。新型朊病毒生物学会议：基础科学、诊断与治疗
EMBO Rep. 2002 Dec;3(12):1123-6. doi: 10.1093/embo-reports/kvf256.
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本文引用的文献
1
Small is not beautiful: antagonizing functions for the prion protein PrP(C) and its homologue Dpl.小并不美好：朊病毒蛋白PrP(C)及其同源物Dpl的拮抗功能
Trends Neurosci. 2002 Mar;25(3):150-4. doi: 10.1016/s0166-2236(00)02089-0.
2
Expression of doppel in the CNS of mice does not modulate transmissible spongiform encephalopathy disease.小鼠中枢神经系统中多普蛋白的表达不会调节传染性海绵状脑病。
J Gen Virol. 2002 Mar;83(Pt 3):705-711. doi: 10.1099/0022-1317-83-3-705.
3
Changing a single amino acid in the N-terminus of murine PrP alters TSE incubation time across three species barriers.改变小鼠朊蛋白（PrP）N端的单个氨基酸会改变跨三个物种屏障的传染性海绵状脑病（TSE）潜伏期。
EMBO J. 2001 Sep 17;20(18):5070-8. doi: 10.1093/emboj/20.18.5070.
4
Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies.通过抗朊病毒蛋白抗体的转基因表达预防羊瘙痒病发病机制。
Science. 2001 Oct 5;294(5540):178-82. doi: 10.1126/science.1063093. Epub 2001 Sep 6.
5
Crystal structure of the human prion protein reveals a mechanism for oligomerization.人类朊病毒蛋白的晶体结构揭示了一种寡聚化机制。
Nat Struct Biol. 2001 Sep;8(9):770-4. doi: 10.1038/nsb0901-770.
6
Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay.使用高灵敏度免疫印迹法检测变异型克雅氏病中蛋白酶抗性朊病毒蛋白的组织分布
Lancet. 2001 Jul 21;358(9277):171-80. doi: 10.1016/s0140-6736(01)05403-4.
7
Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding.通过蛋白质错误折叠循环扩增对病理性朊病毒蛋白进行灵敏检测。
Nature. 2001 Jun 14;411(6839):810-3. doi: 10.1038/35081095.
8
Studies on peptide fragments of prion proteins.朊病毒蛋白肽片段的研究。
Adv Protein Chem. 2001;57:171-201. doi: 10.1016/s0065-3233(01)57022-9.
9
A protease-resistant prion protein isoform is present in urine of animals and humans affected with prion diseases.一种抗蛋白酶的朊病毒蛋白异构体存在于患有朊病毒疾病的动物和人类的尿液中。
J Biol Chem. 2001 Aug 24;276(34):31479-82. doi: 10.1074/jbc.C100278200. Epub 2001 Jun 21.
10
Doppel is an N-glycosylated, glycosylphosphatidylinositol-anchored protein. Expression in testis and ectopic production in the brains of Prnp(0/0) mice predisposed to Purkinje cell loss.多配体蛋白（Doppel）是一种N-糖基化的、糖基磷脂酰肌醇锚定蛋白。在易发生浦肯野细胞丢失的Prnp(0/0)小鼠的睾丸中表达并在其大脑中异位产生。
J Biol Chem. 2000 Sep 1;275(35):26834-41. doi: 10.1074/jbc.M003888200.
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