[血管紧张素原基因单倍型与原发性高血压的关系]
[The relationship between haplotypes of angiotensinogen gene and essential hypertension].
作者信息
Kong Xiangdong, Zhang Sizhong, Yang Yuxia, Zheng Keqin, Tong Yu, Shi Jiajun, Zhang Kelan, Su Zhiguang, Cheng Wei
机构信息
Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P. R. China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002 Dec;19(6):488-90.
OBJECTIVE
To investigate the relationship between the polymorphism of angiotensinogen gene (AGT) and the risk for hypertension in a Chinese population.
METHODS
Three polymorphisms of AGT gene were analyzed in 335 patients with documented essential hypertension and 196 control subjects by using PCR-restriction fragment length polymorphism. Expectation maximization(EM) algorithm was then used for pairwise linkage disequilibrium test and haplotype analysis of AGT polymorphisms.
RESULTS
Linkage disequilibrium between M235T and A-20C, between M235T and A-6G, between A-20C and A-6G was observed (P<10(-4)). The case-control analysis revealed that the frequency of T235 is significantly higher in essential hypertension patients than in control subjects. But all haplotype frequencies showed no significant difference between the patient and control groups.
CONCLUSION
No association was noted between the haplotypes of AGT gene and hypertension in tested people, but T235 allele might play an important role in increased risk for essential hypertension.
目的
研究血管紧张素原基因（AGT）多态性与中国人群高血压患病风险之间的关系。
方法
采用聚合酶链反应-限制性片段长度多态性方法，对335例确诊的原发性高血压患者和196例对照者的AGT基因三种多态性进行分析。然后使用期望最大化（EM）算法对AGT多态性进行成对连锁不平衡检验和单倍型分析。
结果
观察到M235T与A-20C之间、M235T与A-6G之间、A-20C与A-6G之间存在连锁不平衡（P<10⁻⁴）。病例对照分析显示，原发性高血压患者中T235的频率显著高于对照组。但患者组和对照组之间所有单倍型频率均无显著差异。
结论
在受试人群中，未发现AGT基因单倍型与高血压之间存在关联，但T235等位基因可能在原发性高血压患病风险增加中起重要作用。
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