Frieri Marianne
Departments of Medicine, Pediatrics, and Pathology, Division of Allergy Immunology, Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554, USA.
Allergy Asthma Proc. 2002 Sep-Oct;23(5):319-24.
This review article will consider some basic aspects of complement biology, address the clinical effects of hereditary complement deficiencies and the role of complement related to host cell entry, pathogenesis of infectious diseases, and apoptosis. The immunomodulation of autoimmune and inflammatory disorders related to complement components, the role of intravenous gamma-globulin and mechanisms of autoimmune urticaria and tolerance will be discussed briefly.
这篇综述文章将探讨补体生物学的一些基本方面，阐述遗传性补体缺陷的临床影响以及补体在宿主细胞进入、传染病发病机制和细胞凋亡方面的作用。还将简要讨论与补体成分相关的自身免疫性和炎症性疾病的免疫调节、静脉注射丙种球蛋白的作用以及自身免疫性荨麻疹和耐受性的机制。
