放线菌素D、硫唑嘌呤和氢化可的松对小鼠干扰素和抗体形成的比较作用
[The comparative effects of actinomycin D, imuren and hydrocortisone on interferon and antibody formation in mice].
作者信息
Solov'ev V D, Sorokin A M
出版信息
Biull Eksp Biol Med. 1976 Jan;81(1):53-4.
A single dose of actinomycin-D (2.5 mg/kg body wt) reduced the interferon formation 16-fold in comparison with control; as to the antibody production - it was completely abolished. Hydrocortiosone (100 mg/kg) also diminished the interferon production 16-fold, but had no effect on the production of antibodies against the virus. The effect of hydrocortisone on the antiviral immunity was similar to that of the antilymphocytic serum, whereas the action of actinomycin-D resembled the effect of the X-ray irradiation or imuran. The data obtained were consistent with the suggestion on the heterogeneity of cells, participating in the interferon production in the organism.
与对照组相比，单次注射放线菌素D（2.5毫克/千克体重）可使干扰素生成量降低16倍；至于抗体产生——则完全被抑制。氢化可的松（100毫克/千克）也使干扰素生成量减少16倍，但对针对该病毒的抗体产生没有影响。氢化可的松对抗病毒免疫的作用与抗淋巴细胞血清相似，而放线菌素D的作用类似于X射线照射或硫唑嘌呤的作用。所获得的数据与关于机体中参与干扰素产生的细胞具有异质性的观点一致。
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