He Bin, Li Guanglin, Zhang Xin
The University of Illinois at Chicago, Department of Bioengineering, 60607, USA.
Phys Med Biol. 2002 Nov 21;47(22):4063-78. doi: 10.1088/0031-9155/47/22/310.
We propose a new method for imaging activation time within three-dimensional (3D) myocardium by means of a heart-excitation model. The activation time is estimated from body surface electrocardiograms by minimizing multiple objective functions of the measured body surface potential maps (BSPMs) and the heart-model-generated BSPMs. Computer simulation studies have been conducted to evaluate the proposed 3D myocardial activation time imaging approach. Single-site pacing at 24 sites throughout the ventricles, as well as dual-site pacing at 12 pairs of sites in the vicinity of atrioventricular ring, was performed. The present simulation results show that the average correlation coefficient (CC) and relative error (RE) for single-site pacing were 0.9992+/-0.0008/0.9989+/-0.0008 and 0.05+/-0.02/0.07+/-0.03, respectively, when 5 microV/10 microV Gaussian white noise (GWN) was added to the body surface potentials. The average CC and RE for dual-site pacing were 0.9975+/-0.0037 and 0.08+/-0.04, respectively, when 10 microV GWN was added to the body surface potentials. The present simulation results suggest the feasibility of noninvasive estimation of activation time throughout the ventricles from body surface potential measurement, and suggest that the proposed method may become an important alternative in imaging cardiac electrical activity noninvasively.
我们提出了一种通过心脏兴奋模型对三维（3D）心肌内激活时间进行成像的新方法。通过最小化测量的体表电位图（BSPM）和心脏模型生成的BSPM的多个目标函数，从体表心电图估计激活时间。已进行计算机模拟研究以评估所提出的3D心肌激活时间成像方法。在整个心室的24个部位进行单部位起搏，以及在房室环附近的12对部位进行双部位起搏。当前的模拟结果表明，当向体表电位添加5μV/10μV高斯白噪声（GWN）时，单部位起搏的平均相关系数（CC）和相对误差（RE）分别为0.9992±0.0008/0.9989±0.0008和0.05±0.02/0.07±0.03。当向体表电位添加10μV GWN时，双部位起搏的平均CC和RE分别为0.9975±0.0037和0.08±0.04。当前的模拟结果表明从体表电位测量无创估计整个心室激活时间的可行性，并表明所提出的方法可能成为无创成像心脏电活动的重要替代方法。
