小鼠和人类的胚胎造血
Embryonic hematopoiesis in mice and humans.
作者信息
Yoder M C
出版信息
Acta Paediatr Suppl. 2002;91(438):5-8. doi: 10.1111/j.1651-2227.2002.tb02899.x.
AIM
The aim of this report is to review briefly the ontogeny of hematopoiesis in mice and humans and to discuss recent evidence for an intraembryonic source of hematopoietic stem cells.
METHODS
The hematopoiesis overview summarizes information present in the PubMed online database and from experiments conducted in our laboratories.
RESULTS
The major sites of hematopoiesis change throughout development in mice and humans. Recent evidence suggests that hematopoietic cells may emerge from mesoderm precursors within the embryo as well as in the yolk sac.
CONCLUSION
The ontogeny of hematopoiesis is similar in mice and humans. The murine system is a useful model to study the earliest events involved in forming hematopoietic stem cells.
目的
本报告旨在简要回顾小鼠和人类造血作用的个体发生过程，并讨论造血干细胞胚胎内来源的最新证据。
方法
造血作用概述总结了在线数据库PubMed中的信息以及我们实验室进行的实验结果。
结果
小鼠和人类在整个发育过程中造血的主要部位会发生变化。最近的证据表明，造血细胞可能源自胚胎内以及卵黄囊内的中胚层前体细胞。
结论
小鼠和人类的造血个体发生过程相似。小鼠系统是研究形成造血干细胞所涉及的最早事件的有用模型。
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