Dame C
Division of Neonatology, Department of Pediatrics, University of Florida, College of Medicine, Gainesville, Florida 32610-0296, USA.
Acta Paediatr Suppl. 2002;91(438):54-65. doi: 10.1111/j.1651-2227.2002.tb02900.x.
This review focuses on the biology of thrombopoietin (Tpo) during human development. It summarizes the current understanding on molecular biological aspects of Tpo, cellular effects of Tpo on fetal and neonatal megakaryopoiesis, regulation of Tpo production, and circulating Tpo concentrations in human fetuses and neonates. Some important aspects on the developmental biology of Tpo are highlighted. They include the finding of high Tpo gene expression in the bone marrow during the onset of medullary hematopoiesis, higher circulating Tpo concentrations in fetuses and neonates than in children or adults, and a higher sensitivity of neonatal megakaryocyte progenitor cells to Tpo. However, other aspects of the developmental biology of Tpo are incompletely understood.
More carefully designed studies are needed to provide the necessary background for an optimal treatment of fetal and neonatal thrombocytopenia.
本综述聚焦于人类发育过程中血小板生成素（Tpo）的生物学特性。它总结了目前对Tpo分子生物学方面的认识、Tpo对胎儿和新生儿巨核细胞生成的细胞效应、Tpo产生的调节以及人类胎儿和新生儿循环中Tpo的浓度。强调了Tpo发育生物学的一些重要方面。它们包括在髓系造血开始时骨髓中Tpo基因高表达的发现、胎儿和新生儿循环中Tpo浓度高于儿童或成人，以及新生儿巨核细胞祖细胞对Tpo的更高敏感性。然而，Tpo发育生物学的其他方面尚不完全清楚。
需要更精心设计的研究来为优化治疗胎儿和新生儿血小板减少症提供必要的背景知识。
