Christensen Erik I, Verroust Pierre J
Institute of Anatomy, Department of Cell Biology, University of Aarhus, Wilhelm Meyers Allé. Building 233, 8000 Aarhus C, Denmark.
Pediatr Nephrol. 2002 Dec;17(12):993-9. doi: 10.1007/s00467-002-0956-5. Epub 2002 Nov 7.
Epithelia lining the proximal convoluted epithelium and the visceral yolk sac in rodents are characterized by their ability to internalize and degrade many proteins facing their apical pole. It has become apparent over the last decade that this property is mediated through a very high endocytic activity and the expression of at least two distinct multiligand receptors, cubilin and megalin, characterized by the accumulation of ligand-binding units, LDL receptor class A repeats and CUB domains, respectively. We review here evidence that both receptors are involved in proximal tubule function and embryonic development.
啮齿动物近端曲管上皮和脏层卵黄囊的上皮细胞，其特征在于能够内化和降解许多面向其顶端极的蛋白质。在过去十年中已经很明显，这种特性是通过非常高的内吞活性以及至少两种不同的多配体受体（分别以配体结合单位、低密度脂蛋白受体A类重复序列和CUB结构域的积累为特征的cubilin和megalin）的表达来介导的。我们在此回顾证据表明这两种受体都参与近端小管功能和胚胎发育。
