Zhang Hong-xin, Liu Yan, Cao Wei, Wang Zhi-min, Guo Wei-ping, Ni Dai-hui, Liu Yi-yong, Wang Yi-qing, Li Wen-xian, Fan Ai-lin, Han Rui-yang
Department of Interventional Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, P. R. China.
Ai Zheng. 2002 Aug;21(8):843-5.
BACKGROUND & OBJECTIVE: It was reported that heating can enhance sensitivity of rabbit VX2 cell to adriamycin and increase intracellular concentration of adriamycin. This study was designed to evaluate the anti-tumor effects of interventional hyperthermia and interventional chemotheramotherapy on VX2 carcinoma in rabbit liver.
VX2 carcinoma cells were surgically implanted into the right liver lobe of 60 male New Zealand white rabbits, which were randomly divided into 4 groups(15 rabbits per group). To inject physiological saline(37 degrees C), adriamycin (37 degrees C), physiological saline(60 degrees C), and adriamycin (60 degrees C) in different groups via hepatic artery of the rabbits with liver cancer. One week later, to observe the volume of tumor, the serum level of aspartate transaminase(AST), and observe the survival period of VX2 rabbits.
In group of ADM(60 degrees C), the tumor growth rate (0.53 +/- 0.21)% was significantly lower than group 2(1.09 +/- 0.26)%, group 3(3.32 +/- 1.28)%, and group 4(3.48 +/- 1.17)% (P < 0.05, P < 0.05, P < 0.01, respectively). The survival period of adriamycin (60 degrees C) group (50.0 +/- 2.0)d was significantly higher than the untreated control group (40.5 +/- 3.0)d, (P < 0.05). The serum level of AST of TNP-470 with lipiodol group was not higher than the other treated groups(P > 0.05), but being significantly higher than the untreated control group after treated(P < 0.05).
Adriamycin (60 degrees C) greatly decreases the tumour growth rate, and prolongs the survival period.
有报道称加热可增强兔VX2细胞对阿霉素的敏感性，并增加细胞内阿霉素浓度。本研究旨在评估介入性热疗和介入性化疗对兔肝VX2癌的抗肿瘤作用。
将VX2癌细胞手术植入60只雄性新西兰白兔的右肝叶，随机分为4组（每组15只）。分别经患肝癌兔的肝动脉向不同组注射生理盐水（37℃）、阿霉素（37℃）、生理盐水（60℃）和阿霉素（60℃）。1周后，观察肿瘤体积、血清天冬氨酸转氨酶（AST）水平，并观察VX2兔的生存期。
阿霉素（60℃）组肿瘤生长率（0.53±0.21）%显著低于第2组（1.09±0.26）%、第3组（3.32±1.28）%和第4组（3.48±1.17）%（分别为P<0.05、P<0.05、P<0.01）。阿霉素（60℃）组生存期（50.0±2.0）d显著高于未治疗对照组（40.5±3.0）d（P<0.05）。碘油联合TNP-470组血清AST水平不高于其他治疗组（P>0.05），但治疗后显著高于未治疗对照组（P<0.05）。
阿霉素（60℃）可显著降低肿瘤生长率，延长生存期。
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