Shin S W, Han H, Choo S W, Yoo B C, Park C K, Do Y S, Lee J H, Lee D H, Choi D, Choo I-W, Kim S S, Lee J Y
Department of Radiology, Kangwon National University College of Medicine, Kangwon-do, Korea.
Acta Radiol. 2006 Dec;47(10):1036-41. doi: 10.1080/02841850600977752.
To evaluate the antitumoral effects of an intra-arterial injection of 3-bromopyruvate (3-BrPA) on liver VX2 tumor in rabbits.
Twenty rabbits with surgically implanted liver VX2 tumors were used. The rabbits were divided into three groups: a control, a saline, and a 3-BrPA group. Four rabbits were not treated at all, and they served as the control group. The saline group (n = 6) received only intra-arterial saline injection. The 3-BrPA group (n = 10) received an intra-arterial injection of 3-bromopyruvate through the hepatic artery. The delivered amounts of 3-bromopyruvate were as follows: 25 ml of 0.5 mM in six rabbits, 25 ml of 1.0 mM in two rabbits, and 25 ml of 2.0 mM in two rabbits. Four days after intra-arterial injection, the rabbits were sacrificed and histopathologic analysis of the explanted livers was performed with comparison of the tumor necrosis ratio (a percentage of the necrotic area versus the entire tumorous area) in each group.
The mean tumor necrosis ratio was 12.5+/-4.2%, 44.8+/-24.7%, and 49.4+/-14.3% in the control, saline, and 3-BrPA groups, respectively. Between the control and the saline group, and between the control and the 3-BrPA group the mean tumor necrosis ratio appeared to be significantly different (P<0.05). However, there was no statistical difference in the mean tumor necrosis ratio between the saline and the 3-BrPA group (P = 0.416).
A single session of intra-arterial injection of 3-BrPA showed no better results in terms of tumor necrosis than that of saline injection in a rabbit VX2 tumor model.
评估动脉内注射3-溴丙酮酸（3-BrPA）对兔肝脏VX2肿瘤的抗肿瘤作用。
使用20只手术植入肝脏VX2肿瘤的兔子。将兔子分为三组：对照组、生理盐水组和3-BrPA组。4只兔子未接受任何治疗，作为对照组。生理盐水组（n = 6）仅接受动脉内注射生理盐水。3-BrPA组（n = 10）通过肝动脉接受动脉内注射3-溴丙酮酸。3-溴丙酮酸的给药量如下：6只兔子给予25 ml 0.5 mM，2只兔子给予25 ml 1.0 mM，2只兔子给予25 ml 2.0 mM。动脉内注射4天后，处死兔子，对取出的肝脏进行组织病理学分析，并比较每组的肿瘤坏死率（坏死面积占整个肿瘤面积的百分比）。
对照组、生理盐水组和3-BrPA组的平均肿瘤坏死率分别为12.5±4.2%、44.8±24.7%和49.4±14.3%。对照组与生理盐水组之间以及对照组与3-BrPA组之间的平均肿瘤坏死率差异有统计学意义（P<0.05）。然而，生理盐水组与3-BrPA组之间的平均肿瘤坏死率无统计学差异（P = 0.416）。
在兔VX2肿瘤模型中，单次动脉内注射3-BrPA在肿瘤坏死方面的效果并不优于注射生理盐水。
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