[吸烟对男性精液质量的相关性及影响研究]
[Study of correlation and effect of smoking on semen quality of men].
作者信息
Zhang Jin-Ping, Meng Qing-Yu, Zhang Lei-Jia, Mao Yi-Long, Sun Zhuo-Xiang
机构信息
Department of Histology and Embryology, Jining Medical College, Jining, Shandong 272013, China.
出版信息
Zhonghua Nan Ke Xue. 2002;8(1):35-7.
OBJECTIVES
To study the correlation and effect of smoking on the semen quality of men.
METHODS
61 men, non-smoker, who had one or more children as normal fertility control group and adult males attending the infertility clinic, including 110 non-smokers and 191 smokers, were recruited for the study. The smokers were divided into subgroups according to the amount and duration of smoking. Semen parameters(volume, sperm density, viability, motility and morphology) were examined and seminal plasma contents of Zn, Cu and superoxide dismutase (SOD) were determined.
RESULTS
The semen volume, pH, sperm density, viability and forward progression, as well as the seminal plasma contents of Zn, Cu and SOD were much lower in the medium, heavy and long-term smokers than in the non-smokers(P < 0.01). The sperm density, viability and forward progression, and the seminal plasma Zn, Cu and SOD levels were negatively correlation with the amount and duration of cigarette smoking(P < 0.001).
CONCLUSIONS
The effect of smoking on semen parameters of infertile men were dose-effect and time-effect relationship. Medium, heavy and long-term smoking adversely affected the semen quality in a population of men visiting the infertility clinic.
目的
研究吸烟与男性精液质量的相关性及影响。
方法
招募61名有一个或多个孩子的非吸烟男性作为正常生育对照组，以及前往不孕不育门诊的成年男性，其中包括110名非吸烟者和191名吸烟者参与本研究。吸烟者根据吸烟量和吸烟时长分为亚组。检测精液参数（体积、精子密度、活力、运动能力和形态），并测定精浆中锌、铜和超氧化物歧化酶（SOD）的含量。
结果
中度、重度和长期吸烟者的精液体积、pH值、精子密度、活力和前向运动能力，以及精浆中锌、铜和SOD的含量均显著低于非吸烟者（P < 0.01）。精子密度、活力和前向运动能力，以及精浆锌、铜和SOD水平与吸烟量和吸烟时长呈负相关（P < 0.001）。
结论
吸烟对不育男性精液参数的影响呈剂量 - 效应和时间 - 效应关系。中度、重度和长期吸烟对前往不孕不育门诊的男性人群精液质量有不利影响。
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