Harada Y
Cancer Res. 1976 Jan;36(1):18-22.
MRMT-1 is a mammary carcinoma induced in immunologically impaired female Sprague-Dawley rats fed 3-methylcholanthrene. Its biological characteristics include transplantability to syngeneic normal rats and spontaneous metastases to various organs. Hypophysectomy performed 48 hr after tumor inoculation resulted in tumor regression accompanied by the disappearance of the metastasis in lungs of all the animals. The hypophysectomized animals were given replacement treatments, such as transplantation of pituitary homogenates, pituitary homograft underneath the renal capsule, or prolactin administration, and the inhibited tumor growth was markedly reactivated, with the reappearance of lung metastasis. These results indicate that MRMT-1 mammary carcinoma is prolactin dependent.
MRMT-1是在喂食3-甲基胆蒽的免疫受损雌性斯普拉格-道利大鼠中诱发的一种乳腺癌。其生物学特性包括可移植到同基因正常大鼠体内，并能自发转移至各个器官。在肿瘤接种48小时后进行垂体切除，导致肿瘤消退，所有动物肺部的转移灶均消失。对垂体切除的动物进行替代治疗，如移植垂体匀浆、将垂体同种异体移植到肾包膜下或给予催乳素，受抑制的肿瘤生长会明显重新激活，肺部转移灶再次出现。这些结果表明，MRMT-1乳腺癌依赖催乳素。
