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1,25-Dihydroxyvitamin D(3) increases striatal GDNF mRNA and protein expression in adult rats.

作者信息

Sanchez Begoña, Lopez-Martin Elena, Segura Carmen, Labandeira-Garcia Jose L, Perez-Fernandez Roman

机构信息

Department of Physiology, School of Medicine, University of Santiago de Compostela, Spain.

出版信息

Brain Res Mol Brain Res. 2002 Dec;108(1-2):143-6. doi: 10.1016/s0169-328x(02)00545-4.

DOI:10.1016/s0169-328x(02)00545-4
PMID:12480187
Abstract

Glial cell line-derived neurotrophic factor (GDNF) has been postulated as a possible candidate for therapeutic treatment in Parkinson's disease (PD). Recent in vitro data suggest that 1,25-dihydroxyvitamin D3 [1,25(OH)(2)D(3)] treatment may enhance GDNF mRNA expression. In the present study, using semiquantitative RT-PCR and Western blot, we have shown that 1,25(OH)(2)D(3) administration intraperitoneally, significantly increases GDNF mRNA and protein levels in the striatum of adult rats.

摘要

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