Ofori-Kwakye Kwabena, Fell John T
School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, UK.
Int J Pharm. 2003 Jan 2;250(1):251-7. doi: 10.1016/s0378-5173(02)00546-x.
Mixed films containing pectin, chitosan and HPMC, prepared by solvent casting from 0.1 M HCl (pH 1.5) and 0.1 M acetic acid (pH 2.9) were evaluated for their morphological and leaching properties. Films cast at pH 1.5 were uniform with smooth surfaces while films cast at pH 2.9 showed particle aggregation and had rough surfaces due to polyelectrolyte complex (PEC) formation between pectin and chitosan in the medium. The leaching of pectin was higher from films at cast pH 1.5 due to the absence of PEC formation. Pectin leaching was controlled in simulated upper gastrointestinal conditions but was accelerated in the presence of pectinolytic enzymes. The leaching of pectin from the mixed films was a function of the pH of the film casting solvent, pH of the incubation medium, PEC formation and HPMC content.
通过从0.1 M盐酸（pH 1.5）和0.1 M乙酸（pH 2.9）中溶剂浇铸制备的含有果胶、壳聚糖和羟丙基甲基纤维素（HPMC）的混合薄膜，对其形态和溶出特性进行了评估。在pH 1.5浇铸的薄膜表面均匀光滑，而在pH 2.9浇铸的薄膜由于介质中果胶和壳聚糖之间形成聚电解质复合物（PEC）而出现颗粒聚集且表面粗糙。由于未形成PEC，在浇铸pH 1.5的薄膜中果胶的溶出率更高。在模拟的上胃肠道条件下，果胶的溶出受到控制，但在果胶分解酶存在的情况下会加速。混合薄膜中果胶的溶出是薄膜浇铸溶剂的pH、孵育介质的pH、PEC形成和HPMC含量的函数。
