Bijlmakers Marie-José, Marsh Mark
Peter Gorer Department of Immunobiology, Kings College London, 3rd Floor New Guy's House, Guy's Hospital, London SE1 9RT, UK.
Trends Cell Biol. 2003 Jan;13(1):32-42. doi: 10.1016/s0962-8924(02)00008-9.
Palmitoylation is one of the most frequent post-translational modifications found on proteins. It contributes to membrane association, protein sorting and many other processes. Through its reversibility, palmitoylation also provides mechanisms to regulate the functional activities of integral and peripheral membrane proteins. Here we discuss evidence that proteins can be palmitoylated at different locations in the cell, how targeting to these locations might be directed, and aspects of the proposed functions of palmitoylation.
棕榈酰化是蛋白质上最常见的翻译后修饰之一。它有助于膜结合、蛋白质分选及许多其他过程。通过其可逆性，棕榈酰化还提供了调节整合膜蛋白和外周膜蛋白功能活性的机制。在此，我们讨论蛋白质可在细胞内不同位置发生棕榈酰化的证据、靶向这些位置的可能导向方式以及棕榈酰化拟议功能的相关方面。
