Madias J E, Madias N E, Hood W B
Circulation. 1976 Mar;53(3):411-7. doi: 10.1161/01.cir.53.3.411.
Precordial ST-segment mapping was serially applied in the Coronary Care Unit for the study of the effect of oxygen inhalation on the ischemic injury in 17 patients with acute anterior transmural myocardial infarction. A 49-lead ECG system was used. The sum of all ST elevations (sigmaST) recorded was taken as an index of magnitude of ischemic injury and the number of recording sites showing ST elevation (NST) was taken as an index of extent of ischemic damage. Stability of the precordial maps was observed over a period of one hour while the patients were on ambient air. Oxygen inhalation for a mean of 66 min resutled in a fourfold increase of PaO2 and a mean of 16% reduction of both sigmaST and NST. When the patients were returned to ambient air breathing, a mean of 13% increase of sigmaST and 19% of NST from the levels recorded during oxygen inhalation were observed. Levels of sigmaST and NST on ambient air following discontinuation of oxygen inhalation were not significantly different from the corresponding values from maps recorded before onset of oxygen breathing. Blood pressure and heart rate remained unchanged throughout the study. Clinical status of the patients was unchanged during the study period save for two patients who showed changes in intensity of their chest pain.
在冠心病监护病房，对17例急性前壁透壁性心肌梗死患者连续应用心前区ST段标测法，以研究吸氧对缺血性损伤的影响。使用了一个49导联的心电图系统。记录的所有ST段抬高总和（sigmaST）作为缺血性损伤程度的指标，出现ST段抬高的记录部位数量（NST）作为缺血损伤范围的指标。在患者呼吸室内空气的一小时内观察心前区图谱的稳定性。平均吸氧66分钟导致动脉血氧分压（PaO2）增加四倍，sigmaST和NST均平均降低16%。当患者恢复呼吸室内空气时，观察到sigmaST较吸氧时记录的水平平均增加13%，NST增加19%。停止吸氧后呼吸室内空气时的sigmaST和NST水平与吸氧开始前记录的图谱相应值无显著差异。在整个研究过程中，血压和心率保持不变。除两名患者胸痛强度出现变化外，患者的临床状况在研究期间未发生改变。
