玻璃海鞘的基因组草图：对脊索动物和脊椎动物起源的见解。

The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins.

作者信息

Dehal Paramvir, Satou Yutaka, Campbell Robert K, Chapman Jarrod, Degnan Bernard, De Tomaso Anthony, Davidson Brad, Di Gregorio Anna, Gelpke Maarten, Goodstein David M, Harafuji Naoe, Hastings Kenneth E M, Ho Isaac, Hotta Kohji, Huang Wayne, Kawashima Takeshi, Lemaire Patrick, Martinez Diego, Meinertzhagen Ian A, Necula Simona, Nonaka Masaru, Putnam Nik, Rash Sam, Saiga Hidetoshi, Satake Masanobu, Terry Astrid, Yamada Lixy, Wang Hong-Gang, Awazu Satoko, Azumi Kaoru, Boore Jeffrey, Branno Margherita, Chin-Bow Stephen, DeSantis Rosaria, Doyle Sharon, Francino Pilar, Keys David N, Haga Shinobu, Hayashi Hiroko, Hino Kyosuke, Imai Kaoru S, Inaba Kazuo, Kano Shungo, Kobayashi Kenji, Kobayashi Mari, Lee Byung-In, Makabe Kazuhiro W, Manohar Chitra, Matassi Giorgio, Medina Monica, Mochizuki Yasuaki, Mount Steve, Morishita Tomomi, Miura Sachiko, Nakayama Akie, Nishizaka Satoko, Nomoto Hisayo, Ohta Fumiko, Oishi Kazuko, Rigoutsos Isidore, Sano Masako, Sasaki Akane, Sasakura Yasunori, Shoguchi Eiichi, Shin-i Tadasu, Spagnuolo Antoinetta, Stainier Didier, Suzuki Miho M, Tassy Olivier, Takatori Naohito, Tokuoka Miki, Yagi Kasumi, Yoshizaki Fumiko, Wada Shuichi, Zhang Cindy, Hyatt P Douglas, Larimer Frank, Detter Chris, Doggett Norman, Glavina Tijana, Hawkins Trevor, Richardson Paul, Lucas Susan, Kohara Yuji, Levine Michael, Satoh Nori, Rokhsar Daniel S

机构信息

U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.

出版信息

Science. 2002 Dec 13;298(5601):2157-67. doi: 10.1126/science.1080049.

DOI:10.1126/science.1080049

PMID:12481130

Abstract

The first chordates appear in the fossil record at the time of the Cambrian explosion, nearly 550 million years ago. The modern ascidian tadpole represents a plausible approximation to these ancestral chordates. To illuminate the origins of chordate and vertebrates, we generated a draft of the protein-coding portion of the genome of the most studied ascidian, Ciona intestinalis. The Ciona genome contains approximately 16,000 protein-coding genes, similar to the number in other invertebrates, but only half that found in vertebrates. Vertebrate gene families are typically found in simplified form in Ciona, suggesting that ascidians contain the basic ancestral complement of genes involved in cell signaling and development. The ascidian genome has also acquired a number of lineage-specific innovations, including a group of genes engaged in cellulose metabolism that are related to those in bacteria and fungi.

摘要

第一批脊索动物大约在5.5亿年前的寒武纪大爆发时期出现在化石记录中。现代海鞘蝌蚪代表了对这些原始脊索动物的一种合理近似。为了阐明脊索动物和脊椎动物的起源，我们生成了研究最多的海鞘——玻璃海鞘基因组蛋白质编码部分的草图。玻璃海鞘基因组包含约16000个蛋白质编码基因，与其他无脊椎动物的数量相似，但只有脊椎动物中发现数量的一半。脊椎动物的基因家族在玻璃海鞘中通常以简化形式存在，这表明海鞘包含参与细胞信号传导和发育的基本原始基因补充。海鞘基因组还获得了许多特定谱系的创新，包括一组与细菌和真菌中的基因相关的参与纤维素代谢的基因。