de Bont E S J M, Neefjes V M E, Rosati S, Vellenga E, Kamps W A
Division of Pediatric Oncology, Department of Pediatrics, Beatrix Children's Hospital, University Hospital Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
Leuk Lymphoma. 2002 Oct;43(10):1901-9. doi: 10.1080/1042819021000015844.
Although many patients with acute leukemia achieve a hematological complete remission with aggressive intensive therapy protocols, a large proportion shows reoccurrence of disease. Novel strategies are warranted. In acute leukemia new vessel formation is observed. New vessel formation is the result of angiogenesis and vasculogenesis. The degree of neovascularization in the bone marrow is correlated with vascular endothelial growth factor (VEGF) expression in the leukemic cells. The present review discusses the impact of new vessel formation related to acute leukemia, the relation with various angiogenic factors and will focus on VEGF/VEGF receptor signaling.
尽管许多急性白血病患者通过积极的强化治疗方案实现了血液学完全缓解，但仍有很大一部分患者出现疾病复发。因此需要新的策略。在急性白血病中可观察到新血管形成。新血管形成是血管生成和血管发生的结果。骨髓中的新生血管化程度与白血病细胞中血管内皮生长因子（VEGF）的表达相关。本综述讨论了与急性白血病相关的新血管形成的影响、与各种血管生成因子的关系，并将重点关注VEGF/VEGF受体信号传导。
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