Ria R, Roccaro A M, Merchionne F, Vacca A, Dammacco F, Ribatti D
Department of Biomedical Sciences and Human Oncology, Bari, Italy.
Leukemia. 2003 Oct;17(10):1961-6. doi: 10.1038/sj.leu.2403076.
Multiple myeloma (MM) progresses from an avascular to a vascular phase (active MM) accompanied by a significant increase in microvessel density in the bone marrow. This article summarizes the literature concerning the specific role played by vascular endothelial growth factor (VEGF) in this process. Recent applications of antiangiogenic agents that interfere with VEGF signaling and block MM progression are also described.
多发性骨髓瘤（MM）从无血管阶段发展为血管阶段（活跃型MM），同时骨髓微血管密度显著增加。本文总结了有关血管内皮生长因子（VEGF）在此过程中所起特定作用的文献。还描述了干扰VEGF信号传导并阻断MM进展的抗血管生成药物的最新应用。
