Piliotis E, Kutas G, Lipton J H
Princess Margaret Hospital, University Health Network, University of Toronto, 610 University Avenue, Toronto, Ont., Canada M5G 2M9.
Leuk Lymphoma. 2002 Oct;43(10):2051-4. doi: 10.1080/1042819021000016087.
Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative disorder characterized by a clonal proliferation of mainly mature neutrophils, which is often difficult to differentiate from reactive leukocytosis or other myeloproliferative disorders. Treatment to date has focused on disease control rather than cure. Once the disease has progressed to a more aggressive leukemia there is typically little chance of obtaining a long lasting remission due to the older age of most patients as well as the acquisition of multiple poor prognostic cytogenetic abnormalities. In this case report we describe a successful sibling allogeneic bone marrow transplant in a 60-year-old man with CNL performed while he was still in the stable phase of his disease. We propose that even in older patients this curative approach may be considered in selected patients at an early stage of their disease, similar to the approach taken with chronic myelogenous leukemia.
慢性嗜中性粒细胞白血病（CNL）是一种罕见的骨髓增殖性疾病，其特征是主要为成熟嗜中性粒细胞的克隆性增殖，常难以与反应性白细胞增多症或其他骨髓增殖性疾病相鉴别。迄今为止，治疗主要侧重于疾病控制而非治愈。一旦疾病进展为更具侵袭性的白血病，由于大多数患者年龄较大以及出现多种预后不良的细胞遗传学异常，通常几乎没有获得长期缓解的机会。在本病例报告中，我们描述了一名60岁患有CNL的男性在疾病仍处于稳定期时成功进行了同胞异基因骨髓移植。我们建议，即使是老年患者，在疾病早期的特定患者中也可考虑这种治愈性方法，类似于慢性粒细胞白血病的治疗方法。
