[异基因骨髓移植治疗布鲁顿病]
[Allogeneic bone marrow transplantation for the treatment of Bruton disease].
作者信息
Huang Xiaojun, Shi Hongxia, Guo Nailan, Lu Daopei
机构信息
Institute of Hematology, People's Hospital, Peking University, Beijing 100044, China.
出版信息
Zhonghua Xue Ye Xue Za Zhi. 2002 Oct;23(10):528-30.
OBJECTIVE
To explore the efficacy of allogeneic bone marrow transplantation (allo-BMT) for the treatment of Bruton disease.
METHODS
HLA-matched sibling bone marrow transplantation was performed for the treatment of 2 cases of X-linked agammaglobulinemia. One of them received allo-BMT twice.
RESULTS
Recovery of hematopoiesis was gained at day 20 and day 13 after allo-BMT in the two cases respectively. Serum immunoglobin rose gradually to normal level in three months. Their humoral immuno-system was reconstituted and life quality improved. These two patients are still in disease-free survival for 13 and 2 years respectively. There was no serious graft-versus-host-disease.
CONCLUSION
Stem cell transplantation is a choice for the treatment of Bruton disease.
目的
探讨异基因骨髓移植（allo - BMT）治疗布鲁顿病的疗效。
方法
对2例X连锁无丙种球蛋白血症患者进行人类白细胞抗原（HLA）匹配的同胞骨髓移植治疗。其中1例接受了两次allo - BMT。
结果
两例患者分别在allo - BMT后第20天和第13天造血恢复。血清免疫球蛋白在3个月内逐渐升至正常水平。其体液免疫系统得到重建，生活质量改善。这两名患者分别无病生存13年和2年。未发生严重的移植物抗宿主病。
结论
干细胞移植是治疗布鲁顿病的一种选择。
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