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[Allogeneic bone marrow transplantation for a patient with malignant histiocytosis].

作者信息

Zhai M, Hu L, Chen H

出版信息

Zhonghua Xue Ye Xue Za Zhi. 1997 Aug;18(8):395-6.

PMID:15625841
Abstract

OBJECTIVE

To observe the efficacy and side effects of allogeneic bone marrow transplantation (allo-BMT) in the treatment of malignant histiocytosis (MH).

METHODS

After conditioning with chemotherapy and total body irradiation, HLA-A, B, DR, DQ compatible allo-BMT was performed in a patient with MH.

RESULTS

DNA fingerprinting showed engraftment on day 22, bone marrow aspiration showed hypercellularity on day 50, and no abnormal cell was found. The patient developed acute graft-versus-host disease ( II degrees) on day 40 and herpes zoster 6 months post-transplantation, and the patient has survived disease-freely for 24 months after allo-BMT.

CONCLUSION

This is the first report of treatment of MH with allo-BMT in China, showing that allo-BMT may significantly prolong the survival of MH.

摘要

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