Sato T, Kogawa K, Iyama S, Kobayashi D, Sato Y, Kuribayashi K, Takada K, Hagiwara S, Oku T, Takahashi S, Matsunaga T, Takahashi M, Terui T, Kato J, Niitsu Y
Department of Internal Medicine (Section 4), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Japan.
Ann Hematol. 2002 Dec;81(12):739-43. doi: 10.1007/s00277-002-0561-5. Epub 2002 Nov 9.
Peripheral T-cell lymphomas (PTCL) account for about 10% of all lymphomas in Western countries, respond poorly to therapy, and have short survival with no sustained remission. Furthermore, the complication of hemophagocytic syndrome (HPS) sometimes makes the prognosis of this disease extremely worse. We report here a case of PTCL with an angiocentric growth pattern complicated with HPS successfully treated by high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Our case suggests this approach is an excellent candidate for the treatment of this disease.
外周T细胞淋巴瘤（PTCL）在西方国家约占所有淋巴瘤的10%，对治疗反应不佳，生存期短且无持续缓解。此外，噬血细胞综合征（HPS）的并发症有时会使这种疾病的预后极其恶化。我们在此报告一例具有血管中心生长模式的PTCL合并HPS患者，通过大剂量化疗和自体外周血干细胞移植成功治愈。我们的病例表明，这种方法是治疗该疾病的极佳选择。
