Tatsumi Mitsuaki, Clark Paul A, Nakamoto Yuji, Wahl Richard L
Division of Nuclear Medicine, Department of Radiology, The Johns Hopkins Medical Institutions, 601 N. Caroline St., Rm 3223, Baltimore, MD 21287-0817, USA.
Eur J Nucl Med Mol Imaging. 2003 Jan;30(1):40-5. doi: 10.1007/s00259-002-0980-5. Epub 2002 Oct 11.
Obtaining consistent high image quality is desirable for clinical positron emission tomography (PET). Body morphology may impact image quality. The purpose of this study was to define the average and the range of body sizes in patients undergoing tumor PET studies in our center and to determine how the body habitus affects the statistical and visual quality of PET images. Height, weight, body surface area (BSA), and body mass index (BMI) were determined in 101 male and 101 female patients (group 1) referred for clinical PET. The summed total counts from three consecutive transaxial slices on non-attenuation-corrected (NAC) 2D fluorine-18 fluorodeoxyglucose (FDG) PET images, which included the largest liver section and no lesions, were determined and compared with body morphology and injected doses (ID) in a representative group of 30 male and 30 female patients (group 2) spanning a range of body morphologies. The visual quality of images was also evaluated using a scoring system by three readers. The average height, weight, and BSA were greater in male than in female patients, but the average BMI was not different between them in group 1. The largest value of weight or BMI was more than four times the smallest value in female patients. The total true counts were best correlated with ID/weight (mCi/kg) in group 2 ( r=0.929, P<0.0001). Intermediate to high total counts (930,000 or more) corresponded to ID/weight of 0.22 or higher. The average visual score was positively correlated with the total counts (rho=0.63, P<0.0001) and with ID/weight (rho=0.68, P<0.0001) on NAC images. The image quality in 22 (84.6%) of 26 patients with intermediate to high total counts was adequate to good, whereas that in 21 (61.8%) of 34 patients with lower total counts was suboptimal. A wide variety of body morphologies was observed in patients referred for clinical FDG-PET tumor studies in our center. The total counts and average image visual score were negatively correlated with weight. Counts in heavy patients were as low as one-fourth those in light patients. Adjusting injected FDG dose in each patient on the basis of body weight may be more appropriate to achieve consistent PET image quality than giving a fixed injected FDG dose.
对于临床正电子发射断层扫描（PET）而言，获得一致的高图像质量是很有必要的。身体形态可能会影响图像质量。本研究的目的是确定在我们中心接受肿瘤PET研究的患者的平均体型和体型范围，并确定身体习性如何影响PET图像的统计质量和视觉质量。对101名男性和101名女性患者（第1组）进行了临床PET检查，测定了他们的身高、体重、体表面积（BSA）和体重指数（BMI）。在一组涵盖多种身体形态的30名男性和30名女性患者（第2组）中，测定了未进行衰减校正（NAC）的二维氟-18氟脱氧葡萄糖（FDG）PET图像上连续三个横断面切片的总计数，这些切片包括最大的肝脏部分且无病变，并将其与身体形态和注射剂量（ID）进行比较。还由三位阅片者使用评分系统对图像的视觉质量进行了评估。在第1组中，男性患者的平均身高、体重和BSA均高于女性患者，但平均BMI在两者之间并无差异。女性患者中体重或BMI的最大值是最小值的四倍多。在第2组中，总真计数与ID/体重（mCi/kg）的相关性最好（r = 0.929，P < 0.0001）。中等至高总计数（930,000或更高）对应于0.22或更高的ID/体重。平均视觉评分与NAC图像上的总计数（rho = 0.63，P < 0.0001）和ID/体重（rho = 0.68，P < 0.0001）呈正相关。26名总计数中等至高的患者中有22名（84.6%）的图像质量为良好至优秀，而34名总计数较低的患者中有21名（61.8%）的图像质量欠佳。在我们中心接受临床FDG-PET肿瘤研究的患者中观察到了多种身体形态。总计数和平均图像视觉评分与体重呈负相关。肥胖患者的计数低至消瘦患者的四分之一。根据体重调整每位患者的FDG注射剂量可能比给予固定的FDG注射剂量更适合实现一致的PET图像质量。
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