Natsui Shinsuke, Maruyama Michio, Ochiai Takanori, Hasegawa Kumi, Takashima Itaru, Nagahama Takeshi, Ebuchi Masakazu
Dept. of Surgery, Tokyo Metropolitan Ohkubo Hospital.
Gan To Kagaku Ryoho. 2002 Nov;29(12):2188-90.
We studied the pharmacokinetics of CPT-11 with intraperitoneal administration in a patient with a PTCD tube. The patient had advanced gastric cancer with peritoneal metastasis. CPT-11 was administrated in a dose of 40 mg and the intraperitoneal, plasma and bile levels of CPT-11, SN-38 and SN-38 glucuronide (SN-38 GLU) were measured periodically. The results showed that the periodical concentration pattern of CPT-11, SN-38 and SN-38 GLU in the bile was closely related to that of CPT-11 in the abdominal cavity.
我们研究了在一名置有经皮肝穿刺胆道引流（PTCD）管的患者中腹腔内给药CPT-11的药代动力学。该患者患有晚期胃癌伴腹膜转移。给予CPT-11剂量为40mg，并定期测量CPT-11、SN-38和SN-38葡萄糖醛酸苷（SN-38 GLU）的腹腔内、血浆和胆汁水平。结果显示，胆汁中CPT-11、SN-38和SN-38 GLU的定期浓度模式与腹腔内CPT-11的模式密切相关。
