Baba Hiroyuki, Goseki Narihide, Takamatsu Susumu, Nosaka Toshihiro, Teramoto Kenichi, Arii Shigeki, Kumagai Jiro
Dept. of Surgery, Institute of Chemotherapy.
Gan To Kagaku Ryoho. 2002 Nov;29(12):2382-5.
A 48-year-old male patient was admitted to our institution with left hypochondralgia. Preoperative serum CEA was 504 ng/ml. Under a radiological diagnosis of simultaneous double cancer of the pancreas and lung, resection was performed. Pathological study revealed primary pancreatic cancer with lung metastasis. After the operation, serum CEA fell to 55 ng/ml. Seventeen months later, bowel obstruction occurred and serum CEA was 140 ng/ml. One course of systemic chemotherapy, using the combination of CDDP, 5-FU and Leucovorin, was successful. After another three months, however, the same clinical symptoms occurred. With no response to the prior chemotherapy regimen, surgery was undertaken and a mass at the mesentery was removed. Fifty-nine months have passed since the initial operation and the patient is free of disease, though his serum CEA is around 50 ng/ml. In conclusion, there are cases of pancreatic cancer in which tumor dormancy can be achieved by postoperative 5-FU based chemotherapy.
一名48岁男性患者因左季肋部疼痛入住我院。术前血清癌胚抗原（CEA）为504 ng/ml。在放射学诊断为胰腺和肺癌同时发生的双重癌症后，进行了切除术。病理研究显示为原发性胰腺癌伴肺转移。术后，血清CEA降至55 ng/ml。17个月后，发生肠梗阻，血清CEA为140 ng/ml。采用顺铂、5-氟尿嘧啶和亚叶酸联合进行的一个疗程全身化疗取得成功。然而，再过三个月后，出现了相同的临床症状。由于对先前的化疗方案无反应，于是进行了手术，并切除了肠系膜处的一个肿块。自初次手术以来已过去59个月，患者病情缓解，尽管其血清CEA约为50 ng/ml。总之，存在一些胰腺癌病例，其中通过术后基于5-氟尿嘧啶的化疗可实现肿瘤休眠。
