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利血平对犬甲状旁腺高钙灌注的影响。

Influence of reserpine on high calcium perfusion of thyro-parathyroid glands in dogs.

作者信息

Zileli M S, Gedik O

出版信息

Endocrinology. 1976 Jan;98(1):176-8. doi: 10.1210/endo-98-1-176.

DOI:10.1210/endo-98-1-176
PMID:1248441
Abstract

Perfusion of the thyro-parathyroid glands in the dog with calcium-rich blood led to a significant decrease (P less than 0.001) in the systemic plasma calcium level. On the other hand, injection of reserpine (0.2 mg/kg ip) 16 and 2 h prior to infusion of hypercalcemic blood into thyro-parathyroid glands did not alter the systemic plasma calcium level significantly (P less than 0.05). This result provides evidence that reserpine blocks the release of hypocalcemic factor from the thyro-parathyroid glands in response to perfusion of high concentrations of calcium.

摘要

用富含钙的血液灌注狗的甲状腺-甲状旁腺,会导致全身血浆钙水平显著降低(P<0.001)。另一方面,在向甲状腺-甲状旁腺灌注高钙血症血液前16小时和2小时腹腔注射利血平(0.2mg/kg),并未显著改变全身血浆钙水平(P<0.05)。这一结果证明,利血平可阻止甲状腺-甲状旁腺在高浓度钙灌注时释放降钙因子。

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