类固醇生成急性调节蛋白是类固醇合成中的一个重要成分，在大脑的特定区域表达。
An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain.
作者信息
King Steven R, Manna Pulak R, Ishii Tomohiro, Syapin Peter J, Ginsberg Stephen D, Wilson Kevin, Walsh Lance P, Parker Keith L, Stocco Douglas M, Smith Roy G, Lamb Dolores J
机构信息
Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030-3498, USA.
出版信息
J Neurosci. 2002 Dec 15;22(24):10613-20. doi: 10.1523/JNEUROSCI.22-24-10613.2002.
Abstract
Recent data implicate locally produced steroids, termed neurosteroids, as regulators of neuronal function. Adrenal and gonadal steroidogenesis is controlled by changes in the steroidogenic acute regulatory protein (StAR); however, little is known about the regulation of neurosteroid production. We now demonstrate unequivocally that StAR mRNA and protein are expressed within glia and neurons in discrete regions of the mouse brain, and that glial StAR expression is inducible. Consistent with a role in de novo neurosteroidogenesis, StAR colocalizes with the cholesterol side-chain cleavage enzyme P450(scc) in both mouse and human brains. These data support a role for StAR in the production of neurosteroids and identify potential sites of active de novo steroid synthesis in the brain.
摘要
最近的数据表明，局部产生的类固醇，即神经甾体，是神经元功能的调节因子。肾上腺和性腺的类固醇生成受类固醇生成急性调节蛋白（StAR）变化的控制；然而，关于神经甾体产生的调节知之甚少。我们现在明确证明，StAR mRNA和蛋白在小鼠脑的离散区域的神经胶质细胞和神经元中表达，并且神经胶质细胞中的StAR表达是可诱导的。与从头合成神经甾体的作用一致，在小鼠和人脑中，StAR与胆固醇侧链裂解酶P450（scc）共定位。这些数据支持StAR在神经甾体产生中的作用，并确定了脑中从头合成类固醇的潜在活性位点。
相似文献
1
An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain.类固醇生成急性调节蛋白是类固醇合成中的一个重要成分，在大脑的特定区域表达。
J Neurosci. 2002 Dec 15;22(24):10613-20. doi: 10.1523/JNEUROSCI.22-24-10613.2002.
2
Steroidogenic acute regulatory (StAR) protein and cholesterol side-chain cleavage (P450scc)-regulated steroidogenesis as an organ-specific molecular and cellular target for endocrine disrupting chemicals in fish.类固醇生成急性调节（StAR）蛋白和胆固醇侧链裂解酶（P450scc）调节的类固醇生成作为鱼类内分泌干扰化学物质的器官特异性分子和细胞靶点。
Cell Biol Toxicol. 2008 Dec;24(6):527-40. doi: 10.1007/s10565-008-9069-7. Epub 2008 Apr 9.
3
Steroidogenic acute regulatory protein: its presence and function in brain neurosteroidogenesis.类固醇生成急性调节蛋白：其在脑内神经甾体生成中的存在及功能
Arch Histol Cytol. 2004 Dec;67(5):383-92. doi: 10.1679/aohc.67.383.
4
The steroidogenic acute regulatory protein is expressed in steroidogenic cells of the day-old brain.类固醇生成急性调节蛋白在新生大脑的类固醇生成细胞中表达。
Endocrinology. 2004 Oct;145(10):4775-80. doi: 10.1210/en.2003-1740. Epub 2004 Jun 17.
5
Neurosteroids: the StAR protein in the brain.神经甾体：大脑中的类固醇生成急性调节蛋白
J Neuroendocrinol. 2004 Sep;16(9):787-93. doi: 10.1111/j.1365-2826.2004.01226.x.
6
Retinoic acids induce neurosteroid biosynthesis in human glial GI-1 Cells via the induction of steroidogenic genes.视黄酸通过诱导甾体生成基因诱导人神经胶质 GI-1 细胞中的神经甾体生物合成。
J Biochem. 2009 Dec;146(6):917-23. doi: 10.1093/jb/mvp142. Epub 2009 Sep 10.
7
Econazole and miconazole inhibit steroidogenesis and disrupt steroidogenic acute regulatory (StAR) protein expression post-transcriptionally.益康唑和咪康唑抑制类固醇生成，并在转录后破坏类固醇生成急性调节（StAR）蛋白的表达。
J Steroid Biochem Mol Biol. 2000 Dec 31;75(4-5):229-36. doi: 10.1016/s0960-0760(00)00170-9.
8
Mitochondrial specificity of the early steps in steroidogenesis.类固醇生成早期步骤的线粒体特异性。
J Steroid Biochem Mol Biol. 1995 Dec;55(5-6):607-16. doi: 10.1016/0960-0760(95)00212-x.
9
Steroidogenic acute regulatory (StAR) protein and cholesterol side-chain cleavage (P450scc) as molecular and cellular targets for 17alpha-ethynylestradiol in salmon previtellogenic oocytes.类固醇生成急性调节（StAR）蛋白和胆固醇侧链裂解酶（P450scc）作为17α-乙炔雌二醇在鲑鱼卵黄生成前卵母细胞中的分子和细胞靶点。
Chem Res Toxicol. 2007 Dec;20(12):1811-9. doi: 10.1021/tx700228g. Epub 2007 Nov 15.
10
Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain.神经甾体生物合成：肾上腺类固醇生成酶的基因在大脑中表达。
Brain Res. 1993 Dec 3;629(2):283-92. doi: 10.1016/0006-8993(93)91332-m.
引用本文的文献
1
Expanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptides.拓展我们对精神疾病中（不）适应性应激生理学的理解：实现类固醇和神经肽的单细胞特征分析
Neurobiol Stress. 2025 Jun 6;37:100739. doi: 10.1016/j.ynstr.2025.100739. eCollection 2025 Jul.
2
Sex Differences in the Lacrimal Gland: Implications for Dry Eye Disease.泪腺中的性别差异：对干眼病的影响。
Int J Mol Sci. 2025 Apr 18;26(8):3833. doi: 10.3390/ijms26083833.
3
Central nervous system mechanisms of salt-sensitive hypertension.盐敏感性高血压的中枢神经系统机制。
Physiol Rev. 2025 Oct 1;105(4):1989-2032. doi: 10.1152/physrev.00035.2024. Epub 2025 May 2.
4
Single cell resolution of neurosteroidogenesis in the murine brain: de novo biosynthesis.小鼠大脑中神经甾体生成的单细胞分辨率：从头生物合成
J Endocrinol. 2025 May 7;265(3). doi: 10.1530/JOE-24-0318. Print 2025 Jun 1.
5
Local Effects of Steroid Hormones within the Bone Microenvironment.骨微环境内类固醇激素的局部作用。
Int J Mol Sci. 2023 Dec 14;24(24):17482. doi: 10.3390/ijms242417482.
6
Steroid Hormones as Modulators of Emotional Regulation in Male Urogenital Cancers.甾体激素作为男性泌尿生殖系统癌症情绪调节的调节剂。
Int J Behav Med. 2023 Dec;30(6):836-848. doi: 10.1007/s12529-022-10139-w. Epub 2022 Dec 2.
7
Sex steroid hormone synthesis, metabolism, and the effects on the mammalian olfactory system.性类固醇激素的合成、代谢及其对哺乳动物嗅觉系统的影响。
Cell Tissue Res. 2023 Jan;391(1):19-42. doi: 10.1007/s00441-022-03707-9. Epub 2022 Nov 19.
8
Steroid hormone regulation of immune responses in cancer.癌症中免疫反应的类固醇激素调节
Immunometabolism (Cobham). 2022 Oct 31;4(4):e00012. doi: 10.1097/IN9.0000000000000012. eCollection 2022 Oct.
9
Neurosteroids (allopregnanolone) and alcohol use disorder: From mechanisms to potential pharmacotherapy.神经甾体（别孕烯醇酮）与酒精使用障碍：从机制到潜在的药物治疗。
Pharmacol Ther. 2022 Dec;240:108299. doi: 10.1016/j.pharmthera.2022.108299. Epub 2022 Oct 30.
10
Revisiting steroidogenesis and its role in immune regulation with the advanced tools and technologies.重新审视类固醇生成及其在免疫调节中的作用，采用先进的工具和技术。
Genes Immun. 2021 Jul;22(3):125-140. doi: 10.1038/s41435-021-00139-3. Epub 2021 Jun 14.
本文引用的文献
1
Dendritic spine formation in response to progesterone synthesized de novo in the developing Purkinje cell in rats.大鼠发育中的浦肯野细胞中，对新合成的孕酮产生反应的树突棘形成。
Neurosci Lett. 2002 Apr 5;322(2):111-5. doi: 10.1016/s0304-3940(02)00077-0.
2
Inducible nitric oxide synthase expression in mesencephalic astrocyte cultures.中脑星形胶质细胞培养物中诱导型一氧化氮合酶的表达
Proc West Pharmacol Soc. 2001;44:117-9.
3
Neurosteroids: biochemistry and clinical significance.神经甾体：生物化学与临床意义
Trends Endocrinol Metab. 2002 Jan-Feb;13(1):35-43. doi: 10.1016/s1043-2760(01)00503-3.
4
The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: distinct mechanisms?孕烯醇酮硫酸盐的合成对映体在大鼠和小鼠的记忆方面具有非常高的活性，甚至比其生理性神经甾体对应物的活性还高：机制不同？
Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):14033-7. doi: 10.1073/pnas.241503698.
5
Tracking the role of a star in the sky of the new millennium.探寻一颗恒星在新千年天空中的角色。
Mol Endocrinol. 2001 Aug;15(8):1245-54. doi: 10.1210/mend.15.8.0697.
6
Neurosteroid synthesis by cytochrome p450-containing systems localized in the rat brain hippocampal neurons: N-methyl-D-aspartate and calcium-dependent synthesis.位于大鼠脑海马神经元中的含细胞色素P450系统合成神经甾体：N-甲基-D-天冬氨酸和钙依赖性合成。
Endocrinology. 2001 Aug;142(8):3578-89. doi: 10.1210/endo.142.8.8327.
7
Steroidogenic factor-1 expression in marmoset and rat hippocampus: co-localization with StAR and aromatase.狨猴和大鼠海马体中类固醇生成因子-1的表达：与类固醇急性调节蛋白和芳香化酶的共定位
J Neurochem. 2001 Mar;76(6):1879-86. doi: 10.1046/j.1471-4159.2001.00207.x.
8
Diametric effects of bacterial endotoxin lipopolysaccharide on adrenal and Leydig cell steroidogenic acute regulatory protein.细菌内毒素脂多糖对肾上腺和睾丸间质细胞类固醇生成急性调节蛋白的直径效应
Endocrinology. 2000 Nov;141(11):4000-12. doi: 10.1210/endo.141.11.7780.
9
The steroidogenic acute regulatory protein homolog MLN64, a late endosomal cholesterol-binding protein.类固醇生成急性调节蛋白同源物MLN64，一种晚期内体胆固醇结合蛋白。
J Biol Chem. 2001 Feb 9;276(6):4261-9. doi: 10.1074/jbc.M006279200. Epub 2000 Oct 26.
10
Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons.阿尔茨海默病中含缠结的CA1神经元中转录本的表达谱
Ann Neurol. 2000 Jul;48(1):77-87.
Zotero 插件