烟碱型受体介导了暴露于尼古丁的斑马鱼胚胎中脊髓运动神经元发育和轴突寻路的变化。
Nicotinic receptors mediate changes in spinal motoneuron development and axonal pathfinding in embryonic zebrafish exposed to nicotine.
作者信息
Svoboda Kurt R, Vijayaraghavan Sukumar, Tanguay Robert L
机构信息
Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA.
出版信息
J Neurosci. 2002 Dec 15;22(24):10731-41. doi: 10.1523/JNEUROSCI.22-24-10731.2002.
Abstract
We show that transient exposure of embryonic zebrafish to nicotine delays the development of secondary spinal motoneurons. Furthermore, there is a long-lasting alteration in axonal pathfinding in secondary motoneurons that is not ameliorated by drug withdrawal. These effects of nicotine were reversed by mammalian nicotinic receptor antagonists. Coupled with these changes is a long-term alteration in swimming behavior. Our results show that transient embryonic exposure to nicotine leads to long-lasting effects on the vertebrate nervous system. These results also demonstrate that the zebrafish is a useful model to examine the effects of nicotine specifically, and drugs of abuse in general, on the development of the CNS in vertebrates.
摘要
我们发现，胚胎期斑马鱼短暂接触尼古丁会延迟次级脊髓运动神经元的发育。此外，次级运动神经元的轴突导向存在长期改变，且这种改变不会因停药而改善。尼古丁的这些作用可被哺乳动物烟碱受体拮抗剂逆转。与这些变化相伴的是游泳行为的长期改变。我们的结果表明，胚胎期短暂接触尼古丁会对脊椎动物神经系统产生持久影响。这些结果还证明，斑马鱼是一个有用的模型，可用于具体研究尼古丁以及一般滥用药物对脊椎动物中枢神经系统发育的影响。
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