Schneider Frank, Putzier Michael
Department of Orthopaedics, Charite University Hospital, Humboldt University, Berlin, Germany.
Spine (Phila Pa 1976). 2002 Dec 15;27(24):E545-7. doi: 10.1097/00007632-200212150-00026.
A retrospective review of a case of primary leptomeningeal melanoma.
To present a previously undescribed tumor of the lumbar meninges.
The case described the first report of lumbar localization and of bony metastasis of this tumor.
The authors present a case of a 65-year-old man with a destruction of the fifth lumbar vertebra and an exacerbation of lumbar pain and acute sensorimotor radiculopathy.
The histologic examination of the resected tissue after the transpedicular stabilization suggested the presence of metastatic melanoma. After the development of progressive paraplegia and a second operation, subsequent histologic examination of the resected tissue showed the lesion to be a primary leptomeningeal melanoma. The patient's condition deteriorated progressively, and 31 days after confirmation of the diagnosis, he died of meningeal melanomatosis.
By indicating the possibility of hitherto unreported sites of occurrence, routes of metastatic spread, and manifestations of this malignant tumor, this case report may contribute to the further elucidation of this disease.
对一例原发性软脑膜黑色素瘤病例进行回顾性研究。
呈现一例此前未被描述的腰椎脑膜肿瘤。
该病例描述了此肿瘤腰椎定位及骨转移的首例报告。
作者报告了一例65岁男性病例，其第五腰椎椎体破坏，伴有腰痛加重及急性感觉运动性神经根病。
经椎弓根内固定术后切除组织的组织学检查提示存在转移性黑色素瘤。在出现进行性截瘫并进行二次手术后，对切除组织的后续组织学检查显示该病变为原发性软脑膜黑色素瘤。患者病情逐渐恶化，确诊后31天死于脑膜黑色素沉着症。
通过指出这种恶性肿瘤迄今未报告的发生部位、转移途径及表现的可能性，本病例报告可能有助于进一步阐明该疾病。
