同型半胱氨酸与开角型青光眼风险
Homocysteine and risk of open-angle glaucoma.
作者信息
Bleich S, Jünemann A, von Ahsen N, Lausen B, Ritter K, Beck G, Naumann G O H, Kornhuber J
机构信息
Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University, Schwabachanlage 6-10, D-91054 Erlangen-Nuremberg, Federal Republic of Germany.
出版信息
J Neural Transm (Vienna). 2002 Dec;109(12):1499-504. doi: 10.1007/s007020200097.
Homocysteine levels and the frequency of heterozygous methylenetetrahydrofolate reductase (MTHFR) C677T mutation are increased in open-angle glaucoma. Since homocysteine can induce vascular injury, alterations in extracellular matrix remodelling, and neuronal cell death, these findings may have important implications for understanding glaucomatous optic neuropathy.
在开角型青光眼中，同型半胱氨酸水平以及杂合型亚甲基四氢叶酸还原酶（MTHFR）C677T突变的频率会升高。由于同型半胱氨酸可诱导血管损伤、细胞外基质重塑改变以及神经元细胞死亡，这些发现可能对理解青光眼性视神经病变具有重要意义。
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