Virgos C, Martorell L, Simó J M, Valero J, Figuera L, Joven J, Labad A, Vilella E
Hospital Psiquiàtric Universitari Institut Pere Mata, Ctra. de l'institut Pere Mata, Reus, Spain.
Neuroreport. 1999 Jul 13;10(10):2035-8. doi: 10.1097/00001756-199907130-00008.
Disturbances in methyl-carbon metabolism, which result in hyperhomocysteinemia, have been associated with schizophrenia. Homozygosity for the T677 allele of the methylenetetrahydrofolate reductase (MTHFR) gene, which encodes for a thermolabile enzyme associated with hyperhomocysteinemia, has been found to be increased in schizophrenic patients. We have investigated whether plasma homocysteine concentration and the frequency of C677T MTHFR variant were increased in schizophrenic inpatients of a psychiatric hospital (n=210) compared with controls (n=218). There were no significant differences in plasma homocysteine concentrations between the schizophrenia and the control group. The distributions of T allele and TT genotype frequencies were similar in both groups (40% and 15%). These results show that impaired homocysteine metabolism is unlikely in schizophrenia.
导致高同型半胱氨酸血症的甲基碳代谢紊乱与精神分裂症有关。编码与高同型半胱氨酸血症相关的热不稳定酶的亚甲基四氢叶酸还原酶（MTHFR）基因的T677等位基因纯合性在精神分裂症患者中有所增加。我们调查了一家精神病医院的210名精神分裂症住院患者与218名对照组相比，血浆同型半胱氨酸浓度和C677T MTHFR变体频率是否增加。精神分裂症组和对照组之间的血浆同型半胱氨酸浓度没有显著差异。两组的T等位基因和TT基因型频率分布相似（分别为40%和15%）。这些结果表明，精神分裂症患者不太可能存在同型半胱氨酸代谢受损的情况。
