Dieterich M
Neurologische Klinik, Johannes-Gutenberg-Universität Mainz.
Nervenarzt. 2002 Dec;73(12):1133-42; quiz 1143. doi: 10.1007/s00115-002-1454-5.
Ischemia,hemorrhages, and other vascular disorders can result in various central or peripheral vestibular syndromes with vertigo, oculomotor/balance disturbances, and nausea. The vascular vertigo syndromes listed in Table 1 can however be brought about by other causes such as demyelitizing focuses in multiple sclerosis or space-occupying lesions, so that not only localization of the damaged structure but also the various etiologies are decisive for the choice of therapy. Occasionally, combined functional disturbances of the peripheral and central vestibular system appear, such as an infarction of the inferior anterior cerebellar artery, which supplies the labyrinth and parts of the brainstem and cerebellum. In rare cases, a central lesion can have the same signs as a peripheral-vertibular disturbance: a lacunar infarct at the root entry zone of the eighth nerve can mimic a unilateral partial loss of labyrinth function as it occurs in vestibular neuritis, thus named "pseudoneuritis". Differential diagnosis between vestibular migraine, vestibular paroxysmia, transient ischemic brainstem attacks, and Meniere's disease is sometimes so difficult that only trial therapies such as prophylaxis with beta blockers, carbamazepine, thrombocyte aggregation inhibitors, antiplatelet drugs, or betahistin can clarify the issue.
缺血、出血及其他血管疾病可导致各种中枢性或外周性前庭综合征,伴有眩晕、眼球运动/平衡障碍及恶心。然而,表1中列出的血管性眩晕综合征也可能由其他原因引起,如多发性硬化中的脱髓鞘病灶或占位性病变,因此,受损结构的定位以及各种病因对于治疗方案的选择都至关重要。偶尔会出现外周和中枢前庭系统的联合功能障碍,例如供应迷路、部分脑干和小脑的小脑下前动脉梗死。在罕见情况下,中枢性病变可能具有与外周性前庭障碍相同的体征:第八神经根入区的腔隙性梗死可模拟前庭神经炎时出现的单侧迷路功能部分丧失,因此称为“假性神经炎”。前庭性偏头痛、前庭阵发性发作、短暂性缺血性脑干发作和梅尼埃病之间的鉴别诊断有时非常困难,以至于只有诸如使用β受体阻滞剂、卡马西平、血小板聚集抑制剂、抗血小板药物或倍他司汀进行预防性治疗等试验性疗法才能明确问题。