Dubnau Josh, Chiang Ann-Shyn, Tully Tim
Cold Spring Harbor Laboratories, 1 Bungtown Rd, Cold Spring Harbor, New York 11724, USA.
J Neurobiol. 2003 Jan;54(1):238-53. doi: 10.1002/neu.10170.
One of the fundamental challenges of modern neuroscience is to understand how memories are acquired, stored, and retrieved by the brain. In the broadest terms, attempts to dissect memory can be broken down into four experimental disciplines: (1) identification of molecular components, (2) ex vivo and in vivo cellular analysis of neuronal function, (3) theoretical modeling approaches of neural systems, and (4) organismal-level behavioral analyses. Our objective here is to offer a conceptually unifying perspective and to discuss this perspective in relation to an experiment analysis of memory in Drosophila.
现代神经科学的基本挑战之一是理解大脑如何获取、存储和检索记忆。从最广泛的意义上讲，剖析记忆的尝试可以分为四个实验学科：（1）分子成分的鉴定，（2）神经元功能的离体和体内细胞分析，（3）神经系统的理论建模方法，以及（4）机体水平的行为分析。我们这里的目标是提供一个概念上统一的观点，并结合果蝇记忆的实验分析来讨论这个观点。
