Fressinaud C, Jean I
Département de Neurologie, UPRES EA 3143, C.H.U., F49033 Angers.
Rev Neurol (Paris). 2002 Jul;158(6-7):713-8.
We report morphometric and immunocytochemical data obtained from nervous biopsy in 7 patients with chronic inflammatory demyelinating neuropathy (CIDP), compared to 5 controls (without neurological involvement). Fiber loss was present in all cases and reached 50 p. 100 or more in 4 cases. The g myelination ratio was elevated in 3 cases only, indicating demyelination. The number of fibers labelled for the L subunit of neurofilaments was normal in cases with moderate fiber loss and dropped down for densities < 3900/mm2 (4 cases). Labelling with anti-GAP43 antibody was considerably increased in 3 cases, but did not correlate with fiber density or disease duration. These data confirm the importance of axonal lesions in CIDP and offer the opportunity to discuss their pathophysiological mechanisms.
我们报告了7例慢性炎症性脱髓鞘性多发性神经病（CIDP）患者神经活检获得的形态学和免疫细胞化学数据，并与5例对照者（无神经受累）进行了比较。所有病例均存在纤维丢失，4例中纤维丢失达到50%或更多。仅3例g髓鞘形成率升高，提示脱髓鞘。在纤维丢失程度中等的病例中，神经丝L亚基标记的纤维数量正常，而在纤维密度<3900/mm²的4例病例中该数量下降。3例中抗GAP43抗体标记显著增加，但与纤维密度或病程无关。这些数据证实了轴索病变在CIDP中的重要性，并为讨论其病理生理机制提供了机会。
