培高利特：治疗帕金森病的一种有效激动剂

[Pergolide: a useful agonist for the treatment of Parkinson disease].

作者信息

Bonnet A M, Houeto J L

机构信息

Fédération de Neurologie, INSERM U289, Hôpital Pitié-Salpêtrière, 47 Bd de L'Hôpital, 75651 Paris.

出版信息

Rev Neurol (Paris). 2002 Jul;158(6-7):744-5.

PMID:12486908

Abstract

The efficiency of pergolide has been confirmed by the study of a group 29 parkinsonian patients. They were relatively young, and the duration of evolution of their Parkinson's disease was more then ten years, with levodopa-induced dyskinesia and fluctuations. In this group of patients with most serious motor disability, it has been possible to improve dyskinesia and fluctuations with a relatively important dosage of pergolide and without increase of levodopa dosage.

摘要

一组29名帕金森病患者的研究证实了培高利特的疗效。他们相对年轻，帕金森病的病程超过十年，伴有左旋多巴诱导的运动障碍和症状波动。在这组运动残疾最为严重的患者中，使用相对较大剂量的培高利特且不增加左旋多巴剂量，已能够改善运动障碍和症状波动。