Samloff I M, Secrist D M, Passaro E
Gastroenterology. 1976 Mar;70(3):309-13.
Serum group I pepsinogen (PG I) levels have been determined by radioimmunoassay in 15 patients without, recurrent ulcer after vagotomy and either a gastric resection or a drainage procedure. The mean (+/-SE) levels were 151.8 +/- 16.9 ng per ml in the patients with recurrent ulcer and 79.7 +/- 9.8 ng per ml in those without recurrence (P less than 0.001). A recurrent ulcer was present in 6 of 7 patients with an elevated serum PGI (greater than 175 ng per ml) but not in any of 10 patients with a low serum PGI (less than 50 ng per ml). The correlation between serum PG I and peak acid output (PAO) was statistically significant in patients with recurrent ulcer (pi=0.815, P less than 0.001) and in those without recurrence (r= 0.540, P less than 0.025). In patients with recurrent ulcer, a serum PG I level within the normal range (50 to 175 ng per ml) was uniformly associated with a PAO of more than 10 mEq per hr. In contrast, of 10 patients without recurrent ulcer and a normal serum PG I, eight had a PAO of less than 10 mEq per hr. The reason for the discordant results in the two groups of patients is not certain.
采用放射免疫分析法测定了15例迷走神经切断术后行胃切除术或引流术但未发生复发性溃疡患者的血清I型胃蛋白酶原（PG I）水平。复发性溃疡患者的平均（±标准误）水平为每毫升151.8±16.9纳克，未复发患者为每毫升79.7±9.8纳克（P<0.001）。血清PGI升高（大于每毫升175纳克）的7例患者中有6例出现复发性溃疡，而血清PGI低（小于每毫升50纳克）的10例患者中无一例出现复发性溃疡。复发性溃疡患者和未复发患者中，血清PG I与最大酸排量（PAO）之间的相关性均具有统计学意义（复发性溃疡患者中pi=0.815，P<0.001；未复发患者中r=0.540，P<0.025）。在复发性溃疡患者中，血清PG I水平在正常范围内（每毫升50至175纳克）均与每小时超过10毫当量的PAO相关。相比之下，10例无复发性溃疡且血清PG I正常的患者中，有8例的PAO低于每小时10毫当量。两组患者结果不一致的原因尚不确定。
