Goedhard J G, Biemond I, Giliams J P, Pals G, Kreuning J
Prog Clin Biol Res. 1985;173:139-46.
We measured serum PG I levels by an Elisa technique before and after stimulation with pentagastrin in 260 patients (161 males and 99 females). The serum levels were correlated to basic acid output (BAO), maximum acid output (MAO) and peak acid output (PAO). The correlation coefficient between serum PG I and PAO varied between -0.482 and 0.744 depending on the diagnosis. This indicates that a simple measurement of PG I cannot replace the pentagastrin test in estimating gastric acid secreting capacity. However, since all patients who were achlorhydric had a serum PG I level of less than 50 micrograms/l the measurement of serum PG I can be recommended as a screening test for achlorhydria.
我们采用酶联免疫吸附测定（ELISA）技术，在260例患者（161例男性和99例女性）接受五肽胃泌素刺激前后测量血清胃蛋白酶原I（PG I）水平。血清水平与基础酸排量（BAO）、最大酸排量（MAO）和高峰酸排量（PAO）相关。根据诊断情况，血清PG I与PAO之间的相关系数在-0.482至0.744之间变化。这表明，在评估胃酸分泌能力时，单纯测量PG I不能替代五肽胃泌素试验。然而，由于所有胃酸缺乏患者的血清PG I水平均低于50微克/升，因此血清PG I测量可作为胃酸缺乏的筛查试验。
