血清胱抑素C浓度作为各种肾脏疾病患者肾小球滤过率的标志物。
Serum cystatin C concentration as a marker of glomerular filtration rate in patients with various renal diseases.
作者信息
Nitta Kosaku, Hayashi Tetsuo, Uchida Keiko, Honda Kazuho, Tsukada Misao, Sekine Shizue, Itabashi Mitsuyo, Yumura Wako, Nihei Hiroshi
机构信息
Department of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo.
出版信息
Intern Med. 2002 Nov;41(11):931-5. doi: 10.2169/internalmedicine.41.931.
OBJECTIVE
The present study was undertaken to evaluate clinical application of serum cystatin C as a new marker of glomerular filtration rate (GFR) in patients with various renal diseases.
PATIENTS AND METHODS
A total of 140 patients were enrolled in the study. We measured the serum cystatin C levels and compared them with creatinine clearance (Ccr) and inulin clearance (Cin) as an indicator of GFR.
RESULTS
There was a significant positive correlation between serum cystatin C and creatinine levels (r=0.928). Serum cystatin C was inversely correlated with creatinine clearance. Moreover, the reciprocal serum cystatin C level was positively correlated with Cin (r=0.882). The receiver-operating characteristic curve of serum cystatin C and creatinine demonstrated that the diagnostic accuracy of the serum cystatin C level is superior to that of creatinine in identifying individuals with reduced GFR.
CONCLUSION
These results indicated that measurement of serum cystatin C is useful to estimate GFR, and in particular, to detect a mild reduction of GFR in patients with renal diseases.
目的
本研究旨在评估血清胱抑素C作为肾小球滤过率（GFR）新标志物在各种肾脏疾病患者中的临床应用。
患者与方法
共有140名患者纳入本研究。我们检测了血清胱抑素C水平，并将其与作为GFR指标的肌酐清除率（Ccr）和菊粉清除率（Cin）进行比较。
结果
血清胱抑素C与肌酐水平之间存在显著正相关（r = 0.928）。血清胱抑素C与肌酐清除率呈负相关。此外，血清胱抑素C水平的倒数与Cin呈正相关（r = 0.882）。血清胱抑素C和肌酐的受试者工作特征曲线表明，在识别GFR降低的个体时，血清胱抑素C水平的诊断准确性优于肌酐。
结论
这些结果表明，检测血清胱抑素C有助于评估GFR，特别是在检测肾脏疾病患者GFR的轻度降低方面。
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