Ishikawa Tetsuro, Onoda Naoyoshi, Ogawa Yoshinari, Takashima Tsutomu, Matsunaga Nobuo, Michigami Shinya, Okamura Terue, Tahara Hideki, Inaba Masaaki, Nakatani Tatsuya, Hirakawa Kosei
Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.
Biomed Pharmacother. 2002;56 Suppl 1:34s-36s. doi: 10.1016/s0753-3322(02)00211-1.
Ectopic parathyroid adenoma or hyperplasia in the mediastinum are seen in a percentage of patients with hyperparathyroidism and have generally been treated by conventional open surgery. However, due to recent improvements in the ability of diagnostic imaging such as 99mTc-methoxyisobutylisonitrile (MIBI) scintigraphy to identify these lesions, we have been obtaining favorable results from thoracoscopic excision of mediastinal parathyroid tumors. In thoracoscopic surgery, three to four trocars were inserted between the fourth and seventh ribs from a lateral approach. Based on diagnostic imaging, tumors were identified and excised by the shortest possible route. Surgery time for four consecutive patients ranged from 50 to 140 min, and hemorrhage volumes were small. No intra- or postoperative complications were observed, and the postoperative course for these patients has been uneventful. Analgesia was required only a few times for each patient. In the most recent patient, radioisotope-navigated thoracoscopic excision was performed using 99mTc-MIBI. When thoracoscopic excision was combined with radioisotope navigation, tumor identification took less time, cutting the surgery time in half and ultimately placing less stress on the patient.
一部分甲状旁腺功能亢进患者可见纵隔异位甲状旁腺腺瘤或增生,以往通常采用传统开放手术治疗。然而,由于近期诊断成像技术如99mTc-甲氧基异丁基异腈(MIBI)闪烁扫描识别这些病变的能力有所提高,我们通过胸腔镜切除纵隔甲状旁腺肿瘤取得了良好效果。在胸腔镜手术中,经外侧入路在第四至第七肋之间插入三到四个套管针。根据诊断成像,确定肿瘤并通过尽可能短的路径切除。连续4例患者的手术时间为50至140分钟,出血量少。未观察到术中或术后并发症,这些患者的术后病程平稳。每位患者仅需少量镇痛。在最近的一例患者中,使用99mTc-MIBI进行放射性核素导航胸腔镜切除。当胸腔镜切除与放射性核素导航相结合时,识别肿瘤所需时间减少,手术时间减半,最终减轻了患者的压力。